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| 1 | Correlation of endoscopic disease severity with pediatric ulcerative colitis activity index score in children and young adults with ulcerative colitis显示文摘AIM To investigate of pediatric ulcerative colitis activity index(PUCAI) in ulcerative colitis correlate with mucosal inflammation and endoscopic assessment of disease activity(Mayo endoscopic score).METHODS We reviewed charts from ulcerative colitis patients who had undergone both colonoscopy over 3 years. Clinical assessment of disease severity within 35 d(either before or after) the colonoscopy were included. Patients were excluded if they had significant therapeutic interventions(such as the start of corticosteroids or immunosuppressive agents) between the colonoscopy and the clinical assessment. Mayoendoscopic score of the rectum and sigmoid were done by two gastroenterologists. Inter-observer variability in Mayo score was assessed.RESULTS We identified 99 patients(53% female, 74% pancolitis) that met inclusion criteria. The indications for colonoscopy included ongoing disease activity(62%), consideration of medication change(10%), assessment of medication efficacy(14%), and cancer screening(14%). Based on PUCAI scores, 33% of patients were in remission, 39% had mild disease, 23% had moderate disease, and 4% had severe disease. There was 'moderate-substantial' agreement between the two reviewers in assessing rectal Mayo scores(kappa = 0.54, 95%CI: 0.41-0.68). CONCLUSION Endoscopic disease severity(Mayo score) assessed by reviewing photographs of pediatric colonoscopy has moderate inter-rater reliability, and agreement was less robust in assessing patients with mild disease activity. Endoscopic disease severity generally correlates with clinical disease severity as measured by PUCAI score. However, children with inflamed colons can have significant variation in their reported clinical symptoms. Thus, assessment of both clinical symptoms and endoscopic disease severity may be required in future clinical studies. | Basavaraj Kerur Heather J Litman Julia Bender Stern Sarah Weber Jenifer R Lightdale Paul A Rufo Athos Bousvaros | 2017 | World Journal of Gastroenterology2017，23，18： | 5 |
| 2 | Procedural complexity independent of P2Y12 reaction unit(PRU)values is associated with acute in situ thrombosis in Pipeline flow diversion of cerebral aneurysms显示文摘background Acute in situ thrombosis is an ischaemic phenomenon during Pipeline embolisation device(PED)procedures with potentially high morbidity and mortality.There is controversy regarding the role of platelet function testing with P2Y12 assay as a predictor of intraprocedural thromboembolic events.There is limited knowledge on whether procedural complexity influences these events.Methods Data were collected retrospectively on 742 consecutive PED cases at a single institution.Patients with intraprocedural acute thrombosis were compared with patients without these events.results A cohort of 37 PED cases with acute in situ thrombosis(mean age 53.8 years,mean aneurysm size 8.4 mm)was matched with a cohort of 705 PED cases without intraprocedural thromboembolic events(mean age 56.4 years,mean aneurysm size 6.9 mm).All patients with in situ thrombosis received intra-arterial and/or intravenous abciximab.The two groups were evenly matched in patient demographics,previous treatment/subarachnoid hemorrhage(SAH)and aneurysm location.There was no statistical difference in postprocedural P2Y12 reaction unit(PRU)values between the two groups,with a mean of 156 in the in situ thrombosis group vs 148 in the control group(p=0.5894).Presence of cervical carotid tortuosity,high cavernous internal carotid artery grade,need for multiple PED and vasospasm were not significantly different between the two groups.The in situ thrombosis group had statistically significant longer fluoroscopy time(60.4 vs 38.4 min,p<0.0001),higher radiation exposure(3476 vs 2160 mGy,p<0.0001),higher rates of adjunctive coiling(24.3% vs 8.37%,p=0.0010)and higher utilisation of balloon angioplasty(37.8% vs 12.2%,p<0.0001).Clinically,the in situ thrombosis cohort had higher incidence of major and minor stroke,intracerebral haemorrhage and length of stay.Conclusions Predictors of procedural complexity(higher radiation exposure,longer fluoroscopy time,adjunctive coiling and need for balloon angioplasty)are associated with acute thrombotic events during PED placement,independent of PRU values. | Bowen Jiang Matthew T Bender Erick M Westbroek Jessica K Campos Li-Mei Lin Risheng Xu Rafael J Tamargo Judy Huang Geoffrey P Colby Alexander L Coon | 2018 | Stroke & Vascular Neurology2018，3，3： | 2 |
| 3 | Partitioning procedures for solving mixed-variables programming problems显示文摘 | Benders J F | 1962 | Numerische Matematik1962，4，： | 1 |
| 4 | Prevention of infectious complications in peritoneal dialysis : best demonstrated practices显示文摘 | Bender FH Bernardini J Piraino B | 2006 | Kidney Int Suppl2006，70，103： | 1 |
| 5 | 显示文摘 | Jolly M R Bender J W | 1999 | J Intell Mater Syst Struct1999，513，： | 1 |
| 6 | Moll energy for rural India显示文摘 | Frauke U René M J Benders | 2009 | Applied Energy2009，86，1： | 1 |
| 7 | Using patch isolation metrics to predict animal movement in binary landscapes显示文摘 | BENDER D J TISCHENDORF L FAHRIG L | 2003 | Landscape Ecology2003，18，1： | 1 |
| 8 | Phamacokinetic study of ranibizumab (Lucentis TM) following subconjunctival,intracameral and intrvitreal administration in rabbits显示文摘 | Damieo LA Gaudreault J Bender BC | 2004 | Invest Ophthalmol Vis Sci2004，45，： | 1 |
| 9 | Medical simulation-based educational intervention for emergency medicine residents in neonatal resuscitation显示文摘 | Lee MO Brown LL Bender J | 2012 | Aead Emerg Med2012，19，5： | 1 |
| 10 | Angiogenesis and yaseular targeting in Ewing sarcoma: a review of preclinical and clinical data显示文摘 | DUBOIS SG MARINA N GLADE- BENDER J | 2010 | Cancer2010，116，3： | 1 |
| 11 | Lunar laser ranging:a c ontinuing legacy of the Apollo program显示文摘 | P L Bender J E Faller | 1994 | Science1994，265，： | 1 |
| 12 | Pullulan,an extracellular glucan from Pu-llularia pullulans显示文摘 | Bender H Lehmann J Wallenfels K | 1959 | Biochim Biophys Acta1959，36，： | 1 |
| 13 | Properties and applications of commercial magnetorheological fluids 显示文摘 | JOLLY M R BENDER J W CARLSON D J | 2000 | Journal of Intelligent Material Systems and Struc- tures2000，10，11： | 1 |
| 14 | Prevention of infectious eomplieationsin peritoneal dialysis:best demonstrated prae-tiees 显示文摘 | Bender FH Bernardini J Piraino B | 2006 | Kidney Int Suppl2006，103，： | 1 |
| 15 | Wave field modification by bathymetric anomalies and resulting shoreline changes:a review with recent results显示文摘 | Bender C J Dean R G | | 0，，： | 1 |
| 16 | Serratia marcescens quinoprotein glucose dehydrogenase activity mediates medium aciditication and inhibition of prodigiosin production by glucose显示文摘 | JFENDER J E BENDER C M STELLA N A | 2012 | Applied and Environmental Microbology2012，78，17： | 1 |
| 17 | Modeling of dry sliding friction dynamics: From heuristic model to physically motivated models and back显示文摘 | BENDER F A LAMPAERT V SWEVERS J | 2004 | Chaos2004，14，2： | 1 |
| 18 | Changes in cerebral hemodynamics and oxygenation in the first 24 hours after birth asphyxia显示文摘 | Val Bel F Dorrepal CA Benders M J | 1993 | Pediatrics1993，92，3： | 1 |
| 19 | A phase Ⅰ trial and pharmacokinetic study of aflibercept (VEGF Trap) in children with refractory solid tumors:a children's oncology group phase Ⅰ consortium report显示文摘 | Glade Bender J Blaney SM Borinstein S | | 0，，18： | 1 |
| 20 | Adherence to inhaled corticosteroids:an ancillary study of the Childhood Asthma Management Program clinical trial显示文摘 | Krishnan J A Bender B G Wamboldt F S | 2012 | J Allergy Clin Immunol2012，129，1： | 1 |
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