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	题名	作者	年代	出处	被引量
1	hsa-miR-29c and hsa-miR-135b differential expression aspotential biomarker of gastric carcinogenesis显示文摘AIM: To investigate the expression profiles of hsa-mi R-29 c and hsa-mi R-135 b in gastric mucosal samples and their values as gastric carcinogenesis biomarkers. METHODS: The expression levels of hsa-mi R-29 c and hsa-mi R-135 b in normal gastric mucosa, non-atrophic chronic gastritis, intestinal metaplasia and intestinaltype gastric adenocarcinoma were analysed using quantitative real-time PCR. The difference between hsa-mi R-29 c and hsa-mi R-135 b expression profiles in the grouped samples was evaluated by ANOVA and Student's t-test tests. The results were adjusted for multiple testing by using Bonferroni's correction. P values ≤ 0.05 were considered statistically significant. To evaluate hsa-mi R-29 c and hsa-mi R-135 b expressions as potential biomarkers of gastric carcinogenesis, we performed a receiver operating characteristic curve analysis and the derived area under the curve, and a Categorical Principal Components Analysis. In silico identification of the genetic targets of hsa-mi R-29 c and hsa-mi R-135 b was performed using different prediction tools, in order to identify possible genes involved in gastric carcinogenesis.RESULTS: The expression levels of hsa-mi R-29 c were higher in normal gastric mucosal samples, and decreased progressively in non-atrophic chronic gastritis samples, intestinal metaplasia samples and intestinal-type gastric adenocarcinoma samples. The expression of hsa-mi R-29 c in the gastric lesions showed that non-atrophic gastritis have an intermediate profile to gastric normal mucosa and intestinal-type gastric adenocarcinoma, and that intestinal metaplasia samples presented an expression pattern similar to that in intestinal-type gastric adenocarcinoma. This micro RNA(mi RNA) has a good discriminatory accuracy between normal gastric samples and(1) intestinal-type gastric adenocarcinoma; and(2) intestinal metaplasia, and regulates the DMNT3 A oncogene. hsa-mi R-135 b is up-regulated in non-atrophic chronic gastritis and intestinal metaplasia samples and down-regulated in normal gastric mucosa and intestinal-type gastric adenocarcinoma samples. Non-atrophic chronic gastritis and intestinal metaplasia are significantly different from normal gastric mucosa samples. hsa-mi R-135 b expression presented a greater discriminatory accuracy between normal samples and gastric lesions. This mi RNA was associated with Helicobacter pylori presence in non-atrophic chronic gastritis samples and regulates the APC and KLF4 tumour suppressor genes.CONCLUSION: Our results provide evidence of epigenetic alterations in non-atrophic chronic gastritis and intestinal metaplasia and suggest that hsa-mi R-29 c and hsa-mi R-135 b are promising biomarkers of gastric carcinogenesis.	Amanda Ferreira Vidal Aline MP Cruz Leandro Magalhães Adenilson L Pereira Ana KM Anaissi Nélisson CF Alves Paulo JBS Albuquerque Rommel MR Burbano Samia Demachki Ândrea Ribeiro-dos-Santos	2016	World Journal of Gastroenterology2016，22，6：	7
2	Increased risk of deep - vein thrombosis in patients with multiplmyeloma receiving thalidomide and chemotherapy显示文摘	Zangari M Anaissie E Barlogic B	2001	Blood2001，98，5：	1
3	Treatment of asperginosis:Clinical prcatice guidelines of the infectious diseases society of America显示文摘	Walsh T J Anaissie E J Denning D W	2008	Clin Infect Dis2008，46，：	1
4	The Hospital Water Supply as a Source of Nosocomial Infections A Plea for Action 显示文摘	Anaissie EJ Penzak SR Dignani MC	2002	Arch Intern Med2002，162，13：	1
5	Treatment of aspergillosis:clinical practice guidelines of the Infectious Diseases Society of America显示文摘	Walsh TJ Anaissie EJ Denning DW		0，，03：	1
6	The epidemiology of hematogenous candidiasis caused by different Candida species 显示文摘	Anaissie E Hzun O	1997	Clin Infect Dis1997，24，：	1
7	Amphotericin B colloidal dispersion vs amphotericin B as therapy for invasive aspergillosis显示文摘	White MH Anaissie EJ Kusne S	1997	Clin Inf Dis1997，24，：	1
8	Treatment of aspergillo- sis: clinical practice guidelines of the Infectious Diseases Society of A- merica 显示文摘	Walsh TJ Anaissie E J Denning DW	2008	Clin Infect Dis2008，46，：	1
9	Treatment of aspergillosis:clinical practice guidelines of the Infectious Diseases Society of America显示文摘	Walsh TJ Anaissie EJ Denning DW	2008	Clin Infect Dis2008，46，3：	1
10	Predictors of adverse outcome in cancer patients with candidemia显示文摘	Anaissie EJ Rex JH Uzun O	1998	Am J Med1998，104，：	1
11	Thalidomide in the management of multiple myeloma 显示文摘	Barlogie B Yricot G Anaissie E		Semin0，，：	1
12	Treatment of aspergillosis:clinical practice guidelines of the Infectious Diseases Society of America显示文摘	Walsh T J Anaissie E J Denning D W		0，，03：	1
13	Pathogenic aspergillus species recovered from a hospital water system: a 3-year prospective study显示文摘	Anaissie E J Stratton SL Dignani MC	2002	Clin Infect Dis2002，34，6：	1
14	Treatment of as- pergillosis : clinical practice guidelines of the Infectious Diseases Society of America显示文摘	Walsh TJ Anaissie E J Denning DW	2008	Clin Infect Dis2008，46，3：	1
15	Treatment of as-pergillosis:clinical practice guidelines of the infectious disea-ses society of america显示文摘	Walsh TJ Anaissie EJ Denning DW	2008	Clin Infect Dis2008，46，3：	1
16	The epidemiology of hematogenous candidiasis caused by different Candida species显示文摘	Abi-Said D Anaissie E Uzun O		0，，：	1
17	Treatment of invasive fungal infections in renally impaired patients with amphotericin B colloidal dispersion 显示文摘	Anaissie E Mattiuzzi G C Noskin G	2013	Antimicrobial Agents & Chemotherapy2013，42，3：	1
18	Treatment of As pergillosis:Clinical Practice Guidelines of the Infectious Disea ses Society of America显示文摘	Walsh TJ Anaissie EJ Denning DW	2008	Clinical Infectious Diseases2008，46，3：	1
19	Treatment of aspergillo- sis: clinical practice guidelines of the Infectious Diseases Society of A- medea 显示文摘	Walsh TJ Anaissie EJ Denning DW	2008	Clin Infect Dis2008，46，3：	1
20	Increaseed risk of deep vein thrombosis in patients with multiple myeloma receiving thalidomide and chemotherapy 显示文摘	Zangari M Anaissie E Barlogie B	2001	Blood2001，98，5：	1

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