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| 1 | Near-infrared fluorescence sentinel lymph node detection in gastric cancer: A pilot study显示文摘AIM: To investigate feasibility and accuracy of nearinfrared fluorescence imaging using indocyanine green: nanocolloid for sentinel lymph node(SLN) detection in gastric cancer.METHODS: A prospective, single-institution, phaseI feasibility trial was conducted. Patients suffering from gastric cancer and planned for gastrectomy were included. During surgery, a subserosal injection of 1.6 m L ICG:Nanocoll was administered around the tumor. NIR fluorescence imaging of the abdominal cavity was performed using the Mini-FLARE? NIR fluorescence imaging system. Lymphatic pathways and SLNs were visualized. Of every detected SLN, the corresponding lymph node station, signal-to-background ratio and histopathological diagnosis was determined. Patients underwent standard-of-care gastrectomy. Detected SLNs outside the standard dissection planes were also resected and evaluated.RESULTS: Twenty-six patients were enrolled. Four patients were excluded because distant metastases were found during surgery or due to technical failure of the injection. In 21 of the remaining 22 patients, at least 1 SLN was detected by NIR Fluorescence imaging(mean 3.1 SLNs; range 1-6). In 8 of the 21 patients, tumor-positive LNs were found. Overall accuracy of the technique was 90%(70%-99%; 95%CI), which decreased by higher p T-stage(100%, 100%, 100%, 90%, 0% for respectively Tx, T1, T2, T3, T4 tumors). All NIR-negative SLNs were completely effaced by tumor. Mean fluorescence signal-to-background ratio of SLNs was 4.4(range 1.4-19.8). In 8 of the 21 patients, SLNs outside the standard resection plane were identified, that contained malignant cells in 2 patients.CONCLUSION: This study shows successful use of ICG:Nanocoll as lymphatic tracer for SLN detection in gastric cancer. Moreover, tumor-containing LNs outside the standard dissection planes were identified. | Quirijn RJG Tummers Leonora SF Boogerd Wobbe O de Steur Floris PR Verbeek Martin C Boonstra Henricus JM Handgraaf John V Frangioni Cornelis JH van de Velde Henk H Hartgrink Alexander L Vahrmeijer | 2016 | World Journal of Gastroenterology2016，22，13： | 9 |
| 2 | Near-infrared fluorescence imaging of a solitary fibrous tumor of the pancreas using methylene blue显示文摘A 67-year-old female presented with unexplained abdominal pain. A contrast-enhanced computed tomography scan of the abdomen incidentally revealed a mass in the uncinate process of the pancreas. This mass was resected and based on histopathological findings, diagnosed as a solitary fibrous tumor (SFT) of the pancreas. A SFT is an extremely rare benign mesenchymal tumor that in 65% of cases affects the visceral pleura but can also affect extra-pleural sites. The intraoperative demarcation of pancreatic tumors, such as SFTs, can bechallenging. In this report, the first clear intraoperative identification of a SFT of the pancreas in a human was shown using near-infrared fluorescence and methylene blue. | Joost R van der Vorst Alexander L Vahrmeijer Merlijn Hutteman Tjalling Bosse Vincent THBM Smit Cornelis JH van de Velde John V Frangioni Bert A Bonsing | 2012 | World Journal of Gastrointestinal Surgery2012，4，7： | 7 |
| 3 | Apixaban versus warfarin in patients with atrial fibrillation显示文摘 | Granger CB Alexander JH McMurray JJ | | New England Journal of Medicine0，，： | 2 |
| 4 | Pegni- vacogin results in near complete FIX inhibition in acute coro- nary syndrome patients: RADAR pharmacokinetic and pharma- codynamic substudy显示文摘 | POVSIC TJ WARGIN WA ALEXANDER JH | 2011 | Eur Heart J2011，32，19： | 1 |
| 5 | Apixaban versus warfarin in patients with atrial fibrillation显示文摘 | Granger CB Alexander JH McMurray JJ | 2011 | N Engl J Med2011，365，11： | 1 |
| 6 | Apixa- ban for reduction in stroke and other thromboembolic events in at- rial fibrillation ( ARISTOTLE ) trial : design and rationale 显示文摘 | LOPES RD ALEXANDER JH AL-KHATIB SM | 2010 | Am Heart J2010，159，3： | 1 |
| 7 | Antithrombotic therapy in heparin-induced thrombocytopenia: guidelines translated for the clinician显示文摘 | Hess CN Becker RC Alexander JH | 2012 | J Thromb Thrombolysis2012，34，4： | 1 |
| 8 | Efficacy and safety of edifoligide, an E2F transcription factor decoy, for prevention of vein graft failure following coronary artery bypass graft surgery: PREVENT IV: A randomized con- trolled trial 显示文摘 | Alexander JH Harley G Harrington RA | 2006 | Cardiology2006，2，4： | 1 |
| 9 | Apixaban versus warfarin in patients with atrial fibriUation显示文摘 | Granger CB Alexander JH McMurray JJ V | 2011 | N EnglJ Med2011，365，： | 1 |
| 10 | Apixaban versus warfarin in patients with atrial fibril- lation显示文摘 | Granger CB Alexander JH MeMurray JJ | 2011 | N Engl J Med2011，365，11： | 1 |
| 11 | Antithrombotie therapy in heparin-induced thromboeytopenia: guidelines translated for the elinieian显示文摘 | Hess CN Becker RC Alexander JH | 2012 | J Thromb Thrombolysis2012，34，4： | 1 |
| 12 | Apixaban,an oral,direct,selective factor Xa inhibitor,in combination with antiplatelet therapy after acute coronary syndrome:results of the Apixaban for Prevention of Acute Ischemic and Safety Events(APPRAISE)trial显示文摘 | Alexander JH Becker RC Bhatt DL | 2009 | Circulation2009，119，22： | 1 |
| 13 | Apixaban versus warfarin in patients with atrial fibrillation 显示文摘 | Granger CB Alexander JH McMurray J J | 2011 | N Engl J Med2011，365，11： | 1 |
| 14 | Recent antiplatelet drug trails in the acute c ornary syndromes显示文摘 | Harrington RA | 1998 | Drugs1998，56，6： | 1 |
| 15 | Apixaban versus Warfarin in Patients with Atrial Fibrillation显示文摘 | Granger CB Alexander JH McMurray JJV | 2011 | N Engl J Med2011，365，： | 1 |
| 16 | Apixabanversus arfarin in patients with atrial fibrillation显示文摘 | Granger CB* Alexander JH McMurray JJ | 2011 | N Engl JMed2011，365，11： | 1 |
| 17 | Apixaban versus warfarin in patients with atrial fibrillation显示文摘 | Granger CB Alexander JH McMurray JJ | 2011 | N Engl J Med2011，365，11： | 1 |
| 18 | Rituximab therapy in two chil- dren with autoimmune thrombotic thrombocytopenic purpura 显示文摘 | Albaramki JH Teo J Alexander SI | 2009 | Pediatr Nephrol2009，24，9： | 1 |
| 19 | Apixaban versus warfarin in patients with atrial fibrillation显示文摘 | Granger CB Alexander JH McMurray JJ | | 0，，： | 1 |
| 20 | A systematic assessment of cardiovascular outcomes in the saxagliptin drug development program for type 2 diabetes 显示文摘 | Frederich R Alexander JH Fiedorek Fr | 2010 | Postgrad Med2010，122，3： | 1 |
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