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| 1 | 1995—2014年7个高收入国家癌症生存率、死亡率和发病率进展:一项以人群为基础的研究显示文摘以人群为基础的癌症生存率可以有效评估癌症防治服务的效果。本研究从7个国家抽取21个肿瘤登记处390万例癌症资料,包括1995—2014年诊断的食道、胃、结肠、宜肠、胰腺、肺和卵巢7类癌症病例,及其截至2015年12月31日的生存状态随访数据。 | Arnold M Rutherford MJ Bardot A 李辉章(编译) | 2019 | 中华预防医学杂志2019，53，12： | 33 |
| 2 | 急性脊髓损伤患者治疗的临床操作指南:关于MRI基线在临床治疗决策与结果预测中作用的几点建议(英文)显示文摘The objective of this guideline is to outline the role of magnetic resonance imaging(MRI) in clinical decision making and outcome prediction in patients with traumatic spinal cord injury(SCI).Methods A systematic review of the literature was conducted to address key questions related to the use of MRI in patients with traumatic SCI.This review focused on longitudinal studies that controlled for baseline neurologic status.A multidisciplinary Guideline Development Group(GDG) used this information,their clinical expertise,and patient input to develop recommendations on the use of MRI for SCI patients.Based on GRADE(Grading of Recommendation,Assessment,Development and Evaluation),a strong recommendation is worded as ' we recommend,' whereas a weaker recommendation is indicated by 'we suggest.' Results Based on the limited available evidence and the clinical expertise of the GDG,our recommendations were:(1) 'We suggest that MRI be performed in adult patients with acute SCI prior to surgical intervention,when feasible,to facilitate improved clinical decision-making'(quality of evidence,very low) and(2) 'We suggest that MRI should be performed in adult patients in the acute period following SCI,before or after surgical intervention,to improve prediction of neurologic outcome '(quality of evidence,low).Conclusions These guidelines should be implemented into clinical practice to improve outcomes and prognostication for patients with SCI. | Fehlings MG Martin AR Tetreault LA Aarabi B Anderson P Arnold PM Brodke D Burns AS Chiba K Dettori JR Furlan JC Hawryluk G Holly LT Howley S Jeji T Kalsi-Ryan S Kotter M Kurpad S Kwon BK Marino RJ Massicotte E Merli G Middleton JW Nakashima H Nagoshi N Palmieri K Singh A Skelly AC Tsai EC Vaccaro A Wilson JR Yee A Harrop JS | 2017 | 中华神经外科疾病研究杂志2017，16，6： | 8 |
| 3 | Mental and physical symptoms associated with lower social support for patients with hepatitis C显示文摘AIM: To systematically examine the impact of the hepatitis C virus (HCV) diagnosis on patients' level of social support in a large-scale study. METHODS: Patients evaluated and treated for HCV in a tertiary referral center were enrolled in a cross-sectional study. Demographic data, functional and emotional status as measured by the Hospital Anxiety and Depression Scale (HAD) and the Sickness Impact Profile (SIP), severity of liver disease, mode of acquisition, and physical and psychiatric comorbidities were collected from patients or abstracted from the medical record. All participants completed a semi-structured interview, addressing questions of social support. RESULTS: A total of 342 patients (mean age 45.2 years; 37% women) were enrolled. Ninety-two (27%) patients described lower levels of support by family and friends. Nearly half of the participants (45%) noted the loss of at least one relationship due to the disease. Fears related to transmitting the disease (25%) were common and often associated with ignorance or even discrimination by others (19%). Nearly one fifth of the patients did not share information about their disease with others to avoid being stigmatized. Lower levels of social support were significantly associated with living alone, being unemployed, being excluded from antiviral therapy, having psychiatric comorbidities, contracting HCV through intravenous drug use, having high levels of anxiety and depression as measured by the HAD and negative mood state as measured by the SIP. Patients reporting lower levels of social support also noted more physical symptoms as measured by the SIP. CONCLUSION: Patients with hepatitis C often face significant social problems, ranging from social isolation to familial stress. The most common concerns reflect a limited insight of patients and their relatives and friends about the disease, the risk factors for its spread, and about potential consequences. Our data suggest that educational interventions targeting support persons and the stressors identified in our findings may lessen or alleviate the social strains patients with hepatitis C experience. | Julie A Blasiole Laura Shinkunas Douglas R LaBrecque Robert M Arnold Susan L Zickmund | 2006 | World Journal of Gastroenterology2006，12，29： | 5 |
| 4 | Risk for emerging bipolar disorder, variants, and symptoms in children with attention deficit hyperactivity disorder, now grown up显示文摘AIM: To determine the prevalence of bipolar disorder(BD) and sub-threshold symptoms in children with attention deficit hyperactivity disorder(ADHD) through 14 years' follow-up, when participants were between 21-24 years old.METHODS: First, we examined rates of BD type Ⅰ?and Ⅱ diagnoses in youth participating in the NIMH-funded Multimodal Treatment Study of ADHD(MTA). We used the diagnostic interview schedule for children(DISC), administered to both parents(DISC-P) and youth(DISCY). We compared the MTA study subjects with ADHD(n = 579) to a local normative comparison group(LNCG, n = 289) at 4 different assessment points: 6, 8, 12, and 14 years of follow-ups. To evaluate the bipolar variants, we compared total symptom counts(TSC) of DSM manic and hypomanic symptoms that were generated by DISC in ADHD and LNCG subjects. Then we sub-divided the TSC into pathognomonic manic(PM) and non-specific manic(NSM) symptoms. We compared the PM and NSM in ADHD and LNCG at each assessment point and over time. We also evaluated the irritability as category A2 manic symptom in both groups and over time. Finally, we studied the irritability symptom in correlation with PM and NSM in ADHD and LNCG subjects.RESULTS: DISC-generated BD diagnosis did not differ significantly in rates between ADHD(1.89%) and LNCG 1.38%). Interestingly, no participant met BD diagnosis more than once in the 4 assessment points in 14 years. However, on the symptom level, ADHD subjects reported significantly higher mean TSC scores: ADHD 3.0; LNCG 1.7; P < 0.001. ADHD status was associated with higher mean NSM: ADHD 2.0 vs LNCG 1.1; P < 0.0001. Also, ADHD subjects had higher PM symptoms than LNCG, with PM means over all time points of 1.3 ADHD; 0.9 LNCG; P = 0.0001. Examining both NSM and PM, ADHD status associated with greater NSM than PM. However, Over 14 years, the NSM symptoms declined and changed to PM over time(df 3, 2523; F = 20.1; P < 0.0001). Finally, Irritability(BD DSM criterion-A2) rates were significantly higher in ADHD than LNCG(χ2 = 122.2, P < 0.0001), but irritability was associated more strongly with NSM than PM(df 3, 2538; F = 43.2; P < 0.0001).CONCLUSION: Individuals with ADHD do not appear to be at significantly greater risk for developing BD, but do show higher rates of BD symptoms, especially NSM. The greater linkage of irritability to NSM than to PM suggests caution when making BD diagnoses based on irritability alone as one of 2(A-level) symptoms for BD diagnosis, particularly in view of its frequent presentation with other psychopathologies. | Ahmed Z Elmaadawi Peter S Jensen L Eugene Arnold Brooke SG Molina Lily Hechtman Howard B Abikoff Stephen P Hinshaw Jeffrey H Newcorn Laurence Lee Greenhill James M Swanson Cathryn A Galanter | 2015 | World Journal of Psychiatry2015，5，4： | 3 |
| 5 | An objective method for grading ultrasound images of carotid artery plague显示文摘 | Arnold A Taylor P Poston R | 2001 | Ultasound Med Biol2001，27，8： | 2 |
| 6 | Computational method to reduce the search space for directed protein evolution显示文摘 | Mayo S L Arnold F H | 2001 | Proc Natl Acad Sci USA2001，98，： | 1 |
| 7 | A preclinical view of cholinesterase inhibitors in neuroprotection; Do they provide more than symptomatic benefits in Alzheimer' s disease?显示文摘 | Nordberg A Arnold SE | 2005 | Trends Pharmacol Sci2005，26，2： | 1 |
| 8 | Thermodynamics of the deacon process显示文摘 | Arnold C W Kobe K A | 1952 | Chem Eng Prog1952，48，6： | 1 |
| 9 | Diagnostic laparoscopy 显示文摘 | Schneider A R Eickhoff A Arnold J C | 2001 | Endoscopy2001，33，1： | 1 |
| 10 | Expression of p53,bcl-2,E-Cadherin,Matrix Metalloproteinase-9,and Tissue Inhibitor of Metalloproteinases-1 in Paired Primary Tumors and Brain Metastasis显示文摘 | Susanne M Arnold A Byron Young | 1999 | Clinical Cancer Research1999，5，10： | 1 |
| 11 | Temperature-insensitive near-infrared spectro scopic measurement of glucose in aqueous solutions显示文摘 | Hazen Kevin H Arnold Mark A Small Gary W | 1994 | Applied Spectroscopy1994，48，4： | 1 |
| 12 | Application of SWAT for the Upper North Bosque Watershed显示文摘 | Saleh A Arnold J G Gassman P W | 2000 | Transactions of the ASAE2000，43，5： | 1 |
| 13 | Improving out- comes in elderly patients with community-acquired pneumonia by adhering to national guidelines显示文摘 | Arnold F W LaJoie A S Brock G N | 2009 | Arch Intern Meal2009，169，16： | 1 |
| 14 | Solid-state digital micro-mirror array spectrometer for Hadamard transform measurements of glucose and lactate in aqueous solutions 显示文摘 | Xiang D Arnold M A | 2011 | Applied Spectroscopy2011，65，10： | 1 |
| 15 | Performance evaluation of evap-orative cooling using whole-building hygrothermal simula-tions显示文摘 | MARIJKE S ARNOLD A | | 0，，14： | 1 |
| 16 | Analytics in higher education: Establishing a common language 显示文摘 | VAN BARNEVELD A ARNOLD K E CAMPBELL J P | 2012 | EDU- CAUSE Learning Initiative2012，，： | 1 |
| 17 | S3 Guideline: Sedation for gastrointestinal endoscopy 2008显示文摘 | A. Riphaus T. Wehrmann B. Weber J. Arnold U. Beilenhoff H. Bitter S. von Delius D. Domagk A. Ehlers S. Faiss D. Hartmann W. Heinrichs M.-L. Hermans C. Hofmann S. In der Smitten M. Jung G. K?hler M. Kraus J. Martin A. Meining J. Radke T. R?sch H. Seifert A | 2009 | Endoscopy2009，，09： | 1 |
| 18 | Systematic review: efficacy and safety of rituximab for adults with idiopathic thrombocytopenic purpura显示文摘 | Arnold D M Dentali F Crowther M A | 2007 | Ann Intern Med2007，146，1： | 1 |
| 19 | Cyclin D1 in breast cancer pathogenesis 显示文摘 | Arnold A Papanikolaou A | 2005 | J Clin Oncol2005，23，18： | 1 |
| 20 | The diabetes em- powerment scale 显示文摘 | Anderson RM Arnold MS Funnell MM et a l | 1995 | Diabetes Care1995，23，6： | 1 |
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