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| 1 | Perspectives on new biomarkers in gastric cancer: Diagnostic and prognostic applications显示文摘Gastric cancer is considered one of the most deadly tumors worldwide. Even with the decline in its incidence, the mortality rate of this disease has remained high, mainly due to its late diagnosis and to the lack of precise prognostic markers. The main purpose of this review is to present genetic, epigenetic and proteomic molecular markers that may be used in a diagnostic and prognostic manner and to discuss the pros and cons of each type of marker for improving clinical practice. In this sense, we observed that the use of genetic markers, especially mutations and polymorphisms, should be carefully considered, as they are strongly affected by ethnicity. Proteomic-based markers show promise, but the higher costs of the associated techniques con-tinue to make this approach expensive for routine use. Alternatively, epigenetic markers appear to be very promising, as they can be detected in bodily fluids as well as tissues. However, such markers must be used carefully because epigenetic changes may occur due to environmental factors and aging. Despite the advances in technology and its access, to date, there are few defined biomarkers of prognostic and diagnostic use for gastric tumors. Therefore, the use of a panel of several approaches(genetic, epigenetic and proteomic) should be considered the best alternative for clinical practice. | Danilo do Rosário Pinheiro Wallax Augusto Silva Ferreira Mariceli Baia Leo Barros Mariana Diniz Araújo Symara Rodrigues-Antunes Bárbara do Nascimento Borges | 2014 | World Journal of Gastroenterology2014，20，33： | 4 |
| 2 | Can baseline ML Flow test results predict leprosy reactions? An investigation in a cohort of patients enrolled in the uniform multidrug therapy clinical trial for leprosy patients in Brazil显示文摘Background:The predictive value of the serology to detection of IgM against the Mycobacterium leprae-derived phenolic glycolipid-I/PGL-I to identify leprosy patients who are at higher risk of developing reactions remains controversial.Whether baseline results of the ML Flow test can predict leprosy reactions was investigated among a cohort of patients enrolled in The Clinical Trial for Uniform Multidrug Therapy for Leprosy Patients in Brazil(U-MDT/CT-BR).Methods:This was a descriptive study focusing on the main clinical manifestations of leprosy patients enrolled in the U-MDT/CT-BR from March 2007 to February 2012 at two Brazilian leprosy reference centers.For research purposes,753 leprosy patients were categorized according to a modified Ridley-Jopling(R&J)classification and according to the development of leprosy reactions(reversal reaction/RR and erythema nodosum leprosum/ENL),and whether they had a positive or negative bacillary index/BI.Results:More than half of the patients(55.5%)reported leprosy reaction:18.3%(138/753)had a RR and 5.4%(41/753)had ENL.Leprosy reactions were more frequent in the first year following diagnosis,as seen in 27%(205/753)of patients,while 19%(142/753)developed reactions during subsequent follow-up.Similar frequencies of leprosy reactions and other clinical manifestations were observed in paucibacillary(PB)and multibacillary(MB)leprosy patients treated with U-MDT and regular MDT(R-MDT)(P=0.43 and P=0.61,respectively).Compared with PB patients,leprosy reactions were significantly more frequent in MB patients with a high BI,and more patients developed RR than ENL.However,RR and neuritis were also reported in patients with a negative BI.At baseline,the highest rate of ML Flow positivity was observed in patients with a positive BI,especially those who developed ENL,followed by patients who had neuritis and RR.Among reaction-free patients,81.9%were ML Flow positive,however,the differences were not statistically significant compared to reactional patients(P=0.45).Conclusions:MB and PB patients treated with R-MDT and U-MDT showed similar frequencies of RR and other clinical manifestations.Positive ML Flow tests were associated with MB leprosy and BI positivity.However,ML Flow test results at baseline showed limited sensitivity and specificity for predicting the development of leprosy reactions. | Emerith Mayra Hungria Regiane Morillas Oliveira Gerson Oliveira Penna Lúcio Cartaxo Aderaldo Maria Araci de Andrade Pontes Rossilene Cruz Heitor de SáGonçalves Maria Lúcia Fernandes Penna Ligia Regina Franco Sansigolo Kerr Mariane Martins de Araújo Stefani Samira Bührer-Sékula | 2016 | Infectious Diseases of Poverty2016，5，1： | 2 |
| 3 | Serum level of lipoprotein (a) is inversely associated with the development of coronary collateral circulation 显示文摘 | Aras D Geyik B Topaloglu S | 2006 | Coron Artery Dis2006，17，2： | 1 |
| 4 | Propolis effects on pro-inflammatory cytokine production and Toll-like receptor 2 and 4 expression in stressed mice显示文摘 | Ana Carolina Pagliarone Cláudio Lera Orsatti Michelle Cristiane Búfalo Fabiane Missima Tatiana Fernanda Bachiega Jo?o Pessoa Araújo Júnior José Maurício Sforcin | 2009 | International Immunopharmacology2009，，11： | 1 |
| 5 | The Kohonen network in- corporating explicit statistics and its application to the travelling salesman problem 显示文摘 | ARAS N OOMMEN B J ALTINEL I K | 1999 | Neural Networks1999，12，9： | 1 |
| 6 | Prevalence of musculoskeletal pain among teachers显示文摘 | Cardoso J P Ribeiro I Q B Araújo T M | 2009 | Revista Brasileira de Epidemiologia2009，，04： | 1 |
| 7 | Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment显示文摘 | Santos L H M L M Araújo A N Fachini A Pena A Delerue-Matos C Montenegro M C B S M | | 0，，： | 1 |
| 8 | Increased accumulation of hexak is (2-methoxy isobutylisonitrile) technetium (1) (99Tcm-MIBI) in osteosarcoma and its metastatic lymph nodes显示文摘 | Caner B Kitapci M Aras T | 1992 | J Nucl Med1992，33，3： | 1 |
| 9 | Antimierobial activity ,antibiotic susceptibility and virulence factors of lactic acid bacteria of aquatic origin intended for use as probioties in aquaculture 显示文摘 | MUSIOZ-ATIENZA E GOMEZ-SAIA B ARA lJJO C | 2013 | BMC microbiology2013，13，： | 1 |
| 10 | An empirical assessment of ecological footprint calculations for Malaysia 显示文摘 | Ara B R | 2009 | Resources Conservation and Recycling2009，53，： | 1 |
| 11 | Industrial application of AISI 4340 steels treated in cathodic cage plasma nitriding technique显示文摘 | RIBEIRO K J B de SOUSA R R M de ARAJO F O | 2008 | Materials Science and Engineering:2008，479，： | 1 |
| 12 | Influence of an anti-an giogenic treatment on 9L gliosarcoma, oxygenation and re sponse to eytotoxic therapy显示文摘 | Teicher B A Holden S A Ara G | 1995 | Int J Cancer1995，61，5： | 1 |
| 13 | Turkey and Eurasia:Frontiers of a New Geographic Imagination显示文摘 | Aras B Fidan H | | 0，，01： | 1 |
| 14 | Climate change threatens European conservation areas显示文摘 | Araújo M B Alagador D Cabeza M | 2011 | Ecology Letters2011，14，5： | 1 |
| 15 | Prostate cancer: canmultiparametric MR imaging help identify patients who arecandidates for active surveillance-显示文摘 | Turkbey B Mani H Aras O | 2013 | Radiology2013，268，1： | 1 |
| 16 | Antiox- idant capacity of polyphenolic extracts from leaves of crataegus lae- vigata and crataegus monogyna(Hawthorn) subjected to drought and cold stress显示文摘 | Ara Kirakosyan Elisabeth Seymour Peter Kaufman B | 2003 | J Agric food chem2003，51，14： | 1 |
| 17 | Bone mineral density measurement in patients with recurrent normocalciuric calcium stone disease显示文摘 | Tugcu V Ozbek E Aras B | 2007 | Urol Res2007，35，1： | 1 |
| 18 | The Kohonen NetworkIncorporating Explicit Statistics and Its Application to the Traveling Salesman Problem显示文摘 | Aras N Oommen B J Altinel I K | 1999 | Neural Networks1999，12，9： | 1 |
| 19 | Prostate cancer: canmultiparametric MR imaging help identify patients who arecandidates for active surveillance? 显示文摘 | Turkbey B Mani H Aras 0 | 2013 | Radiology2013，268，： | 1 |
| 20 | Renal scintigraphy findings in allograft recipients with increased resistance index on Doppler sonography 显示文摘 | Koeabas B Aktas A Aras M | 2008 | Transplant Proc2008，40，： | 1 |
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