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| 1 | Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25显示文摘堵住抗体 ipilimumab 的细胞毒素的 T 淋巴细胞 antigen-4 (CTLA-4 ) 在很少的病人导致变形黑瘤的调停免疫者的长期的控制。尽管 ipilimumab 无疑经由 immunostimulation 施加它的治疗学的效果,这样远的临床上有用的、 immunologically 相关的 biomarkers 预言治疗效率是逃犯的。这里,我们显示出 IL-2 的那中立化或堵住 α并且 βIL-2 受体的子单元(CD25 和 CD122,分别地) 否则在现出症状之前的潜的老鼠模型由 CTLA-4 封锁导致了,废除了 antitumor 效果和 intratumoral T 受动器对规章的房间(Tregs ) 的比率的伴随的改进,它是。CTLA-4 封锁导致了在失去了 FoxP3 表示并且在 regressing 肿瘤积累了的 IL-2-producing 受动器房间与伴随物上升表示 Lag3, ICOS, IL-10 和 Egr2 的一个镇压 CD4 + T 房间子集的减小。当 recombinant IL-2 改进了 CTLA-4 封锁的治疗学的功效时,圈套 IL-2 受体 α(IL-2Rα, sCD25 ) 禁止了 CTLA-4 的 anticancer 效果封锁。在收到 ipilimumab 的 262 个变形黑瘤病人, sCD25 的基线浆液集中代表了全面幸存的独立指示物,与预言到治疗的抵抗的高水平。总的来说,这些结果解开为在 CTLA-4 的 anticancer 活动的 IL-2 和 IL-2 受体的一个角色封锁。重要地,我们的学习提供第一 immunologically 相关的 biomarker,也就是提高的浆液 sCD25,那与黑瘤在病人预言抵抗到 CTLA-4 封锁。 | Dalil Hannani Marie Vetizou David Enot Sylvie Rusakiewicz Nathalie Chaput David Klatzmann Melanie Desbois Nicolas Jacquelot Nadege Vimond Salem Chouaib Christine Mateus James P Allison Antoni Ribas Jedd D Wolchok Jianda Yuan Philip Wong Michael Postow Andrzej Mackiewicz Jacek Mackiewicz Dirk Schadendorff Dirk Jaeger Alan J Korman Keith Bahjat Michele Maio Luana Calabro Michele WL Teng Mark J Smyth Alexander Eggennont Caroline Robert Guido Kroemer Laurence Zitvogel | 2015 | Cell Research2015，25，2： | 14 |
| 2 | Circulating lymphangiogenic growth factors in gastrointestinal solid tumors, could they be of any clinical significance?显示文摘Metastasis is the principal cause of cancer mortality, with the lymphatic system being the first route of tumor dissemination. The glycoproteins VEGF-C and VEGF-D are members of the vascular endothelial growth factor (VEGF) family, whose role has been recently recognized as lymphatic system regulators during embryogenesis and in pathological processes such as inflammation, lymphatic system disorders and malignant tumor metastasis. They are ligands for the VEGFR-3 receptor on the membrane of the lymphatic endothelial cell, resulting in dilatation of existing lymphatic vessels as well as in vegetation of new ones (lymphangiogenesis). Their determination is feasible in the circulating blood by immunoabsorption and in the tissue specimen by immunohistochemistry and reverse transcription polymerase chain reaction (RT-PCR). Experimental and clinicopathological studies have linked the VEGF-C, VEGF-D/VEGFR3 axis to lymphatic spread as well as to the clinical outcome in several human solid tumors. The majority of these data are derived from surgical specimens and malignant cell series, rendering their clinical application questionable, due to subjectivity factors and post-treatment quantification. In an effort to overcome these drawbacks, an alternative method of immunodetection of the circulating levels of these molecules has been used in studies on gastric, esophageal and colorectal cancer. Their results denotethat quantification of VEGF-C and VEGF-D in blood samples could serve as lymph node metastasis predictive biomarkers and contribute to preoperative staging of gastrointestinal malignancies. | Theodore D Tsirlis George Papastratis Kyriaki Masselou Christos Tsigris Antonis Papachristodoulou Alkiviadis Kostakis Nikolaos I Nikiteas | 2008 | World Journal of Gastroenterology2008，14，17： | 12 |
| 3 | Effects of laparoscopic cholecystectomy on lung function:A systematic review显示文摘AIM:To present and integrate findings of studies investigating the effects of laparoscopic cholecystectomy on various aspects of lung function.METHODS:We extensively reviewed literature of the past 24 years concerning the effects of laparoscopic cholecystectomy in comparison to the open procedure on many aspects of lung function including spirometricvalues,arterial blood gases,respiratory muscle performance and aspects of breathing control,by critically analyzing physiopathologic interpretations and clinically important conclusions.A total of thirty-four articles were used to extract information for the meta-analysis concerning the impact of the laparoscopic procedure on lung function and respiratory physiopathology.The quality of the literature reviewed was evaluated by the number of their citations and the total impact factor of the corresponding journals.A fixed and random effect meta-analysis was used to estimate the pooled standardized mean difference of studied parameters for laparoscopic(LC)and open(OC)procedures.A crude comparison of the two methods using all available information was performed testing the postoperative values expressed as percentages of the preoperative ones using the Mann-Whitney two-sample test.RESULTS:Most of the relevant studies have investigated and compared changes in spirometric parameters.The median percentage and interquartile range(IQR)of preoperative values in forced vital capacity(FVC),forced expiratory volume in 1 s and forced expiratory flow(FEF)at 25%-75%of FVC(FEF25%-75%)expressed as percentage of their preoperative values 24 h after LC and OC were respectively as follows:[77.6(73.0,80.0)L vs 55.4(50.0,64.0)L,P<0.001;76.0(72.3,81.0)L vs 52.5(50.0,56.7)L,P<0.001;and 78.8(68.8,80.9)L/s vs 60.0(36.1,66.1)L/s,P=0.005].Concerning arterial blood gases,partial pressure of oxygen[Pa O2(k Pa)]at 24 or 48 h after surgical treatment showed reductions that were significantly greater in OC compared with LC[LC median 1.0,IQR(0.6,1.3);OC median 2.4,IQR(1.2,2.6),P=0.019].Fewer studies have investigated the effect of LC on respiratory muscle performance showing less impact of this surgical method on maximal respiratory pressures(P<0.01);and changes in the control of breathing after LC evidenced by increase in mean inspiratory impedance(P<0.001)and minimal reduction of duty cycle(P=0.01)compared with preoperative data.CONCLUSION:Laparoscopic cholecystectomy seems to be associated with less postoperative derangement of lung function compared to the open procedure. | George D Bablekos Stylianos A Michaelides Antonis Analitis Konstantinos A Charalabopoulos | 2014 | World Journal of Gastroenterology2014，20，46： | 10 |
| 4 | Effects of glutamine supplementation on gut barrier,glutathione content and acute phase response in malnourished rats during inflammatory shock显示文摘AIM: To evaluate the effect of glutamine on intestinal mucosa integrity,glutathione stores and acute phase response in protein-depleted rats during an inflammatory shock. METHODS: Plasma acute phase proteins (APP),jejunal APP mRNA levels,liver and jejunal glutathione concentrations were measured before and one,three and seven days after turpentine injection in 4 groups of control,protein-restricted,protein-restricted rats supplemented with glutamine or protein powder. Bacterial translocation in mesenteric lymph nodes and intestinal morphology were also assessed. RESULTS: Protein deprivation and turpentine injection significantly reduced jejunal villus height,and crypt depths. Mucosal glutathione concentration significantly decreased in protein-restricted rats. Before turpentine oil,glutamine supplementation restored villus heights and glutathione concentration (3.24 ± 1.05 vs 1.72 ± 0.46 μmol/g tissue,P < 0.05) in the jejunum,whereas in the liver glutathione remained low. Glutamine markedly increased jejunal α1-acid glycoprotein mRNA level after turpentine oil but did not affect its plasma concentration. Bacterial translocation in protein-restricted rats was not prevented by glutamine or protein powder supplementation. CONCLUSION: Glutamine restored gut glutathione stores and villus heights in malnourished rats but had no preventive effect on bacterial translocation in our model. | Liliana Belmonte Mose Co■ffier Florence Le Pessot Olga Miralles-Barrachina Martine Hiron Antony Leplingard Jean-Franois Lemeland Bernadette Hecketsweiler Maryvonne Daveau Philippe Ducrotté Pierre Déchelotte | 2007 | World Journal of Gastroenterology2007，13，20： | 6 |
| 5 | Hemobilia as the initial manifestation of cholangiocarcinoma in a hemophilia B patient显示文摘Hemobilia is a rare manifestation of hemophilia and is usually iatrogenic following liver biopsy. There are only few reports of spontaneous hemobilia in hemophilia patients. Cholangiocarcinoma is a well-established cause of hemobilia. We describe a case of a 70-year-old male, with known haemophilia B and a past history of papillotomy, who presented with classical symptoms of hemobilia. The initial diagnostic work-up failed to demonstrate a potential cause of bleeding other than the coagulopathy. Three months later, he was readmitted to our hospital with a second episode of hemobilia. During the second work-up, a cholangiocarcinoma was diagnosed both by imaging studies and by a significant elevation of cancer antigen 19-9. Although hemobilia could be attributed to hemophilia, especially in a patient with previous papillotomy, an underlying malignancy of the biliary tree should be suspected. | Anastassios C Manolakis Andreas N Kapsoritakis Antonis D Tsikouras Fotis D Tsiopoulos Athanassios K Psychos Spyros P Potamianos | 2008 | World Journal of Gastroenterology2008，14，26： | 5 |
| 6 | Extraction and RP-HPLC determination of taxol in rat plasma, cell culture and quality control samples显示文摘A rapid,sensitive,selective and validated reverse phase high-performance liquid chromatography(RP-HPLC)method for the estimation of paclitaxel in micro-sample of rat plasma and in culture of cancer cells was performed in this study.The mobile phase consisted of an optimized mixture of methanol:water:trifluroacetic acid(80:20:0.1,v/v/v).Column elution at a flow rate of 1 mL/minute with UV detection at 225 nm at room temperature was used.The RP-HPLC method was successfully applied for the determination of paclitaxel in plasma samples and in culture of cancer cells with nano-quantity of estimation.The validation studies were performed in accordance with the International Conference on Harmonization(ICH)guidelines.The intra-and inter-day precision showed that the coefficients of variation ranged from 1.07%to 4.27%at different levels of concentrations.To the best of our knowledge,this study also reported for the first time the optimization of different solvents for effective extraction of paclitaxel wherein tert.-butyl methyl ether(TBME):diethyl ether(DEE)in 50:50 v/v composition was found most efficient with extraction efficiency ranging between 77.99%and 91.74%and between 76.14 and 93.66%in the plasma and cell culture,respectively.This proposed method was successfully applied to study the pharmacokinetics of paclitaxel and the influence of verapamil and all-trans retinoic acid(atRA)on paclitaxel pharmacokinetics in rat models.This proposed method might emerge as a valuable aid in the laboratory monitoring of paclitaxel in a variety of in vitro as well as in vivo scenarios. | Rakesh Kumar Tekade Antony D'Emanuele Abdelbary Elhissi Ashish Agrawal Anurekha Jain Basel Tawfiq Arafat Narendra Kumar Jain | 2013 | The Journal of Biomedical Research2013，27，5： | 5 |
| 7 | Blood Pressure Decrease During the Acute Phase of Ischemic Stroke Is Associated With Brain Injury and Poor Stroke Outcome显示文摘 | José Castillo Rogelio Leira María M. García Joaquín Serena Miguel Blanco Antoni Dávalos | 2004 | Stroke: Journal of the American Heart Association2004，，2： | 2 |
| 8 | Plasma Metalloproteinase-9 Concentration Predicts Hemorrhagic Transformation in Acute Ischemic Stroke显示文摘 | Mar Castellanos Rogelio Leira Joaquín Serena José M. Pumar Ignacio Lizasoain José Castillo Antoni Dávalos | 2003 | Stroke: Journal of the American Heart Association2003，，1： | 2 |
| 9 | On the division of attention: A disproof of the single channel hypothesis显示文摘 | Allport D Antonis B Reynolds P | 1972 | Quarterly Journal of Experimental Psychology1972，24，： | 1 |
| 10 | Improving Diamond Coating on Ti6Al4VSubstrate Using a Diamond Like Carbon Interlayer:Raman Residual Stress Evaluation and AFM Analyses显示文摘 | Nibennanoune Z George D Antoni F | 2012 | Diamond&Related Materials2012，22，： | 1 |
| 11 | Evaluation of os- seous metastasis in bone scintigraphy显示文摘 | Davila D Antoniou A Chaudhry MA | 2015 | Semin Nucl Med2015，45，1： | 1 |
| 12 | Does the mind map learning strategy facilitate information retrieval and critical thinking in medical students显示文摘 | D'Antoni AV Zipp GP Olson VG | 2010 | BMC Med Educ2010，，10： | 1 |
| 13 | Percut aneous transluminal angioplasty and stenting in patients with proximal vertebral artery stenosis显示文摘 | Antoniou GA Murray D Georgiadis GS | 2012 | J Vasc Surg2012，55，4： | 1 |
| 14 | The clinical significance of serum and bronchoalveolar lavage inflammatory cytokines in patients at risk for acute respiratory distress syndrome 显示文摘 | Bouros D Alexandrakis MG Antoniou KM | 2004 | BMC Pulm Med2004，4，： | 1 |
| 15 | Effects of antifibrotic agents on TGF-beta1, CTGF and IFN-gamma expression in patients with idiopathic pulmonary fibrosis显示文摘 | Tzortzaki EG Antoniou KM Zervou MI Lambiri I Koutsopoulos A Tzanakis N Plataki M Maltezakis G Bouros D Siafakas NM | 2007 | Respir Med2007，101，8： | 1 |
| 16 | The effect of salt - phase composition on the rate of soda - ash roasting of chromite ores显示文摘 | Tathavadkar V D Antony M P Jha A | 2003 | Metallurgical and Materials Transactions B2003，34，5： | 1 |
| 17 | Increased aortic pulse pressure associated with concentric left ventricular hypertrophy in arterial hypertension显示文摘 | Chemla D Antony I Hebert J | 2002 | AM J Hypertens2002，15，4： | 1 |
| 18 | Treatment of small hepatocellular carcinoma with pereutaneous ethanol injection:a validated prognostic model显示文摘 | Orlando A D'Antoni A Camma C | 2000 | Am J Gastroenterol2000，95，10： | 1 |
| 19 | Lurasidone: a new drug in development for schizophrenia显示文摘 | Jonathan M Meyer Antony D Loebel Edward Schweizer | 2009 | Expert Opinion on Investigational Drugs2009，，： | 1 |
| 20 | Predictive value of D-dimer plasma levels in response and progressive disease in patients with lung cancer显示文摘 | Antoniou D Pavlakou G Stathopoulos G P | 2006 | Lung Cancer2006，53，2： | 1 |
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