|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Molecular detection of Helicobacter pylori antibiotic resistance in stool vs biopsy samples显示文摘AIM To compare(1) demographics in urea breath test(UBT) vs endoscopy patients; and(2) the molecular detection of antibiotic resistance in stool vs biopsy samples.METHODS Six hundred and sixteen adult patients undergoing endoscopy or a UBT were prospectively recruited to the study. The Geno Type Helico DR assay was used to detect Helicobacter pylori(H. pylori) and antibiotic resistance using biopsy and/or stool samples from CLOpositive endoscopy patients and stool samples from UBT-positive patients. RESULTS Infection rates were significantly higher in patients referred for a UBT than endoscopy(overall rates: 33% vs 19%; treatment-na?ve patients: 33% vs 14.7%, respectively). H. pylori-infected UBT patients were younger than H. pylori-infected endoscopy patients(41.4 vs 48.4 years, respectively, P < 0.005), with a higher percentage of H. pylori-infected males in the endoscopy-compared to the UBT-cohort(52.6% vs 33.3%, P = 0.03). The Geno Type Helico DR assay was more accurate at detecting H. pylori infection using biopsy samples than stool samples [98.2%(n = 54/55) vs 80.3%(n =53/66), P < 0.005]. Subset analysis using stool and biopsy samples from CLO-positive endoscopy patients revealed a higher detection rate ofresistance-associated mutations using stool samples compared to biopsies. The concordance rates between stool and biopsy samples for the detection of H. pylori DNA, clarithromycin and fluoroquinolone resistance were just 85%, 53% and 35%, respectively. CONCLUSION Differences between endoscopy and UBT patients provide a rationale for non-invasive detection of H. pylori antibiotic resistance. However, the Geno Type Helico DR assay is an unsuitable approach. | Denise E Brennan Joseph Omorogbe Mary Hussey Donal Tighe Grainne Holleran Colm O'Morain Sinéad M Smith Deirdre McNamara | 2016 | World Journal of Gastroenterology2016，22，41： | 6 |
| 2 | Can bacterial virulence factors predict antibiotic resistant Helicobacter pylori infection?显示文摘AIM To evaluate the association between virulence factor status and antibiotic resistance in Helicobacter pylori(H. pylori)-infected patients in Ireland. METHODS DNA was extracted from antral and corpus biopsies obtained from 165 H. pylori-infected patients. Genotyping for clarithromycin and fluoroquinolone-mediating mutations was performed using the Genotype Helico DR assay. cag A and vac A genotypes were investigated using PCR. RESULTS Primary, secondary and overall resistance rates for clarithromycin were 50.5%(n = 53/105), 78.3%(n = 47/60) and 60.6%(n = 100/165), respectively. Primary, secondary and overall resistance rates for fluoroquinolones were 15.2%(n = 16/105) and 28.3%(n = 17/60) and 20%(n = 33/165), respectively. Resistance to both antibiotics was 12.4%(n = 13/105) in treatment-na?ve patients, 25%(n = 15/60) in those previously treated and 17%(n = 28/165) overall. A cag A-positive genotype was detected in 22.4%(n = 37/165) of patient samples. The dominant vac A genotype was S1/M2 at 44.8%(n = 74/165), followed by S2/M2 at 26.7%(n = 44/165), S1/M1 at 23.6%(n = 39/165) and S2/M1 at 4.8%(n = 8/165). Primary clarithromycin resistance was significantly lower in cag A-positive strains than in cag A-negative strains [32%(n = 8/25) vs 56.3%(n = 45/80); P = 0.03]. Similarly, in patients infected with more virulent H. pylori strains bearing the vac A s1 genotype, primary clarithromycin resistance was significantly lower than in those infected with less virulent strains bearing the vac A s2 genotype, [41%(n = 32/78) vs 77.8%(n = 21/27); P = 0.0001]. No statistically significant association was found between primary fluoroquinolone resistance and virulence factor status.CONCLUSION Genotypic H. pylori clarithromycin resistance is high and cag A-negative strains are dominant in our population. Less virulent(cag A-negative and vac A S2-containing) strains of H. pylori are associated with primary clarithromycin resistance. | Denise E Brennan Colin Dowd Colm O'Morain Deirdre McNamara Sinéad M Smith | 2018 | World Journal of Gastroenterology2018，24，9： | 4 |
| 3 | Ethanol metabolism and its effects on the intestinal epithelial barrier显示文摘 | Elhaseen E Elamin Ad A Masclee Jan Dekker Daisy M Jonkers | 2013 | Nutr Rev2013，，7： | 3 |
| 4 | 视网膜病变、视网膜微血管异常与脑卒中、脑血管病的关系显示文摘视网膜循环异常可能与脑血管病有关。该研究基于英国的三民族人口的基础队列调查了视网膜微血管异常与脑卒中和亚临床脑梗死及脑白质病变之间的相关性。方法:纳入1185名受试者[年龄(68.8±6.1)岁,77%为男性]进行视网膜成像和脑磁共振成像。利用磁共振成像识别脑梗死和脑白质高信号,对视网膜病变进行分级,并测量视网膜血管参数。 | 刘莉 叶鹏 Hughes AD Falaschetti E Witt N Wijetunge S Thom SA Tillin T Aldington SJ Chaturvedi N | 2016 | 中华高血压杂志2016，24，11： | 2 |
| 5 | Delayed reverse sural flap for staged reconstruction of the foot and lower leg显示文摘 | Kneser U Bach AD Polykandriotis E | 2005 | Plastic and Reconstructive Surgery2005，116，7： | 1 |
| 6 | Tract-based spatialstatistics of magnetic resonance images to assess disease andtreatment effects in perinatal asphyxial encephalopathy 显示文摘 | Porter E J Counsell SJ Edwards AD | 2010 | Pediatr Res2010，68，： | 1 |
| 7 | Hematopoietic reconstitution in a patient with Fanconi's anemia by means of umbilicalcord blood from an HLA- identical sihling显示文摘 | Gluckman E BroXllleyer HA Auerbach AD | 1989 | N Engl J Med1989，321，17： | 1 |
| 8 | Hematopoietic reconstitution in a patient with Fanconi's anemia by means of umbilical-cord blood from an HLA-identical sibiling显示文摘 | Gluckman E Broxmeyer HA Auerbach AD | 1989 | N Engl J Med1989，321，17： | 1 |
| 9 | The hordaland homocysteine study:a- community-based study of homocysteine,itsdeterminants,and associa- tions Withdisease显示文摘 | Refsum H Nurk E Smith AD | 2006 | J Nutr2006，136，： | 1 |
| 10 | In vitro evalua- tion of the effect of core diameter for removing radicular post with ultrasound显示文摘 | Alfredo E Garrido AD Souza-Filho CB | 2004 | J Oral Rehabil2004，31，6： | 1 |
| 11 | Organoarsenicals: uptake, metabolism, and toxicity显示文摘 | Dopp E Kligerman AD Diaz-Bone RA | 2010 | Met Ions Life Sci2010，7，： | 1 |
| 12 | Effects of acute exercise on hemorheological,endothelial,and platelet markers in patients with chronic heart failure in sinus rhythm显示文摘 | Gibbs CR Blann AD Edmunds E | 2001 | Clin Cardio12001，24，11： | 1 |
| 13 | The use of the buccal fat pad for reconstruction of oral defects:Review of the literature and report of 15 cases显示文摘 | Rapidis AD Alexandridis CA Elefieriadis E | 2000 | J Oral Maxillofac Surg2000，58，7： | 1 |
| 14 | Thrombomodutm, yon Willebrand factor and E-selectin as plasma markers of endothelial damage/dysfunction and activation in pregnancy induced hypertension显示文摘 | Nadar SK A1Yemeni E Blalm AD eta | 2004 | Thromb Res2004，1152，： | 1 |
| 15 | Trastuzumabfor patients with HER2 positive breast cancer: delivery,duration and combination therapies显示文摘 | Pinto AC Ades F de Azambuja E ef af | 2013 | Breast2013，，2： | 1 |
| 16 | Epigeneties: a landscape takes shape显示文摘 | Goldberg AD Allis CD Bemstein E | 2007 | Cell2007，128，4： | 1 |
| 17 | Late diagnosis of HIV infection:epidemiological features,consequences and strategies to encourage earlier testing显示文摘 | Girardi E Sabin CA Monforte AD | 2007 | J Acquir Immune Defic Syndr2007，461，： | 1 |
| 18 | A contemporary view on endothelial function in heart failure显示文摘 | Shantsila E Wrigley BJ Blann AD | 2012 | Eur J Heart Fail2012，14，8： | 1 |
| 19 | Functional structure of antennal sensiila in the myrmecophilous beetle Paussus favieri (Coleoptera, Carabidae, Paussini) 显示文摘 | Giulio AD Maurizi E Stacconi MVR | 2012 | Micron2012，43，6： | 1 |
| 20 | Synthesis of layeredMCM-22(P) in the presenceof hexamethoniumcations andits transformation into EUO- and MWW-type zeolites 显示文摘 | Goergen S Fay ad E Laforge S | 2011 | Journal of Porous Materials2011，18，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员