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| 1 | Coupled modeling of tumour angiogenesis, tumour growth,and blood perfusion显示文摘This paper proposes a more realistic mathematical simulation method to investigate the dynamic process of tumour angio-genesis by fully coupling the vessel growth,tumour growth and associated blood perfusion.The tumour growth and angiogenesis are coupled by the chemical microenvironment and the cell-matrix interaction.The haemodynamic calculation is carried out on the new vasculature,and an estimation of vessel collapse is made according to the wall shear stress criterion.The results are consistent with physiological observations,and further confirm the application of the coupled model feedback mechanism.The model is available to examine the interactions between angiogenesis and tumour growth,to study the change in the dynamic process of chemical environment and the vessel remodeling. | Y.Cai,1,2 S.X.Xu,1,a) J.Wu,3 and Q.Long 2,b) 1) Department of Mechanics and Engineering Science,Fudan University,Shanghai 200433,China 2) Brunel Institute for Bioengineering,School of Engineering and Design,Brunel University,Uxbridge,Middlesex,UK 3) School of Naval Architecture,Ocean and Civil Engineering,Shanghai Jiaotong University,Shanghai 200240,China | 2011 | Theoretical & Applied Mechanics Letters2011，1，4： | 8 |
| 2 | Effects of disinhibition on spatiotemporal pattern of neuronal first recruitment in neuronal networks显示文摘The propagation of neuronal activities is a key feature to understanding information processing in networks. The analysis based on first-spikes of bursts in turn plays an important role in the research of neuronal activity propagation. Our focus here is to investigate how spatiotemporal patterns of neuronal first-spikes are affected by disinhibition. Multi-electrode arrays were used to record stimulation-evoked bursts of multiple neurons in randomly cultured neuronal networks. Both the precise timing of and the rank relationships between first-spikes were analyzed. Compared with evoked bursts in the network's native state, the precise first-spike latencies in its dis-inhibited state are more consistent and the propagation of its bursting activities is much faster. Additional points of interest are that disinhibited neuronal networks can be evoked to generate stable and distinguishable neuronal first recruitment spatiotemporal patterns specific to the stimulation site, and that the disinhibition may cause the original spatiotemporal patterns to change in a heterogeneous manner with regards to different propagation pathways. | Liangbin Pana,b,c,1, Xindong Songa,b,c,1, Guangxin Xiang a,b,c, Jing Zhua,b,c, Jing Cheng a,b,c,d,a Medical Systems Biology Research Center, Tsinghua University School of Medicine, Beijing 100084, China b Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China c National Engineering Research Center for Beijing Biochip Technology, 18 Life Science Parkway, Beijing 102206, China d State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua University, Beijing 100084, China | 2009 | Progress in Natural Science:Materials International2009，19，5： | 6 |
| 3 | STUDY ON WETLAND LOSS AND ITS REASONS IN CHINA显示文摘Wetlands are ecosystems with many f unctions.But the general public and government lack a comprehen-sive understanding of the importance of wetland benefits,thus making bl indly exploitation,wetland resour ces decreasing and losing biodiversity.So wetlands in China,as in most countries,have suffered heavily from the pressure o f develop-ment and have confronted with the thr eats of loss.The paper takes Sanjian g Plain marshes,lakes in the middle r eaches of the Changjiang(Yangtze)River,coastal wetlands and mangroves as cases to study wetland loss in China,and puts forward main existing reasons of wetland loss,such as blindly reclamati on and exploitation of wetland resou rces,over-exploitation of bio-resource s in wetland,etc.More recently,there has been a growing recognition of t he benefits of wetlands and a wide range of legal and regulatory initiatives have been undertaken which are designed to impro ve wetland management and conservation.On the basis of the above analysis,the paper brings forward some suggestions on wetland conservation. | HE Yan 1 ,ZHANG Ming-xiang 2,3 (1.The Chinese Academy of Sciences,B eijing 100864,P.R.China 2.Changchun Institute of Geography,the Chinese Academy of Sciences,Changchun 130021,P.R.China 3.Wetland Resources Monitoring Center,State Forestry Admi | 2001 | Chinese Geographical Science2001，11，3： | 5 |
| 4 | FLOW MECHANISMS ANDSEDIMENT TRANSPORT IN COMPOUND CHANNELS显示文摘Recent work on the UK Flood Channel Facility (FCF) is described. An overview of tile various experimental programmes. involving overbank flow studies in straight. skewed and meandering channels. is given. Some key results concerning flow mechanisms. resistance. dispcrsion and sediment transport are reviewed. A summary of different methods for estimating the stage-discharge relationship for overbank flows is included. An extensive bibliography is given for those seeking more detailed information. | Donald W. KNIGHT (1 School of Civil Engineering. The University of Birmingham, Edgbaston, Birmingham, B 15 2TT. UK) | 1999 | International Journal of Sediment Research1999，14，2： | 4 |
| 5 | Analysis of species-dependent hydrolysis and protein binding of esmolol enantiomers显示文摘The stereoselective hydrolysis of esmolol in whole blood and in its separated components from rat,rabbit and human was investigated.Blood esterase activities were variable in different species in the order of rat>rabbit>human.Rat plasma showed the high esterase activity and had no stereoselectivity to enantiomers.Rabbit red blood cell(RBC) membrane,RBC cytosol and plasma all hydrolyzed esmolol but with different esterase activity,whereas the hydrolysis in RBC membrane and cytosol showed significant stereoselectivity towards R-(+)-esmolol.Esterase in RBC cytosol from human blood mainly contributed to the esmolol hydrolysis,which was demonstrated with no stereoselctivity.Esterase in human plasma showed a low activity,but a remarkable stereoselectivity with R-(+)-esmolol.In addition,the protein concentration affected the hydrolysis behavior of esmolol in RBC suspension.Protein binding of esmolol enantiomers in human plasma,human serum albumin(HSA) and α_1-acid glycoprotein(AGP) revealed that there was a significant difference in bound fractions between two enantiomers,especially for AGP.Our results indicated that the stereoselective protein binding might play a role in the different hydrolysis rates of esmolol enantiomers in human plasma. | Yi-Hong Tanga,b,1,Jun-Yan Wanga,1,Hai-Hong Hua,Tong-Wei Yaoa,Su Zenga,n aDepartment of Pharmaceutical Analysis and Drug Metabolism,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou,Zhejiang 310058,People’s Republic of China bShanghai Institute of Technology,Shanghai 201418,People’s Republic of China | 2012 | Journal of Pharmaceutical Analysis2012，2，3： | 3 |
| 6 | PHOTOELECTROCHEMICAL STUDY OF PASSIVE LAYERS ON COPPER ELECTRODES IN SOME ALKALINE MEDIA显示文摘PHOTOELECTROCHEMICALSTUDYOFPASSIVELAYERSONCOPPERELECTRODESINSOMEALKALINEMEDIA①A.Kamkina,1,ZhouGuodinga,XuQunjiebandB.H.cLooaE... | A. Kamkina,1, Zhou Guodinga, Xu Qunjieb and B. H.c Loo a Electrochemical Research Group, Shanghai Institute of Electric Power, Shanghai 200090, P. R. China b Corrosion Prevention Center, East China University of | 1998 | 中国有色金属学会会刊:英文版1998，8，2： | 2 |
| 7 | Apoptosis in developing anthers and the role of ABA in this process during androgenesis in Hordeum vulgate L显示文摘 | WANG M HOEKSTRA S VAN BERGEN S LAMERS GEM OPPEDIJK B J VAN DER HEUDEN M W DE PRIESTER W SCHILPEROORT RA 1 | 1999 | Plant Mol Biol1999，39，： | 1 |
| 8 | Multiple drop impact onto a dry solid substrate显示文摘 | ROSIMAN 1 V PRUNET-FOCH B TROPEA C VIGNES-ADLER M | 2002 | Journal of Colloid and Interface Science2002，256，2： | 1 |
| 9 | Localized mediastinal lymph node hyperplasia resembling thymoma 显示文摘 | Castleman B Iverson 1 Menendez VP | 1956 | Cancer1956，9，4： | 1 |
| 10 | A prosp ective study toevaluate the anatomic and functionaloutcome of a transobturator mesh kit ( proliftant erior) for symptom atic cystocele repair 显示文摘 | H inou 1 P Om beletWU B urgerMP | 2008 | JM inim Invasive Gynecol2008，15，5： | 1 |
| 11 | Comparison of prognostic algorithms for estimating remaining useful life of batteries显示文摘 | SAHA B GOEBEL K CHRISTOPHERESN 1 | 2009 | Transactions of the Institute of Measurement and Control2009，31，： | 1 |
| 12 | Linear and nonlinear double-diffusive convection in a saturated anisotropic porous layer with Soret effect and internal heat source显示文摘 | ALTAWALLBEHA A A BHADAURIAB B S HASHIM 1 | 2013 | International Journal of Heat and Mass Transfer2013，59，： | 1 |
| 13 | Further developments of a fuzzy set map comparison approach 显示文摘 | Hagen-Zanker A Straatman B Uljee 1 | 2005 | International Journal of Geographical Information Science2005，19，7： | 1 |
| 14 | GB -splines and their properties显示文摘 | Kvasov B 1 | 1996 | Ann Numer Math1996，3，： | 1 |
| 15 | Acute postinfectious glomerulonephrfis with native aorta valve endocarditis and myopericarditis due to brucellosis显示文摘 | Koeyigit 1 Cellk A Tokgoz B | 2011 | Ren Fall2011，，33： | 1 |
| 16 | Influences of knowledge process in organizational learning: the psychosocial filter显示文摘 | Andrews K M Delahaye B 1 | 2000 | Journal of Management Studies2000，37，6： | 1 |
| 17 | Analyzing and shaping human attentional networks显示文摘 | POSNER M 1 SHEESE B E ODULUDA Y & TANG Y | 2006 | Neural Net- works:the official journal of the International Neural Network Society2006，19，： | 1 |
| 18 | Tidal and storm-surge measurements with single-site CODAR显示文摘 | Lipa B 1 Barrick D E | 1986 | IEEE J Ocean Eng1986，，2： | 1 |
| 19 | Phacoemulsification with and- without trabeculectomy in patients with glaucoma 显示文摘 | Nerbauer H Kirchhof B Yalvac 1 | 2006 | Ophthalmic Sur- gLasers2006，28，4： | 1 |
| 20 | Extraction of titanium, vanadium and iron from titanmagnetite deposits at pipestone lake, Manitoba, Canada显示文摘 | Jena B C Dredler W Reilly 1 G | 1998 | Minerals Engineering1998，8，12： | 1 |
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