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| 1 | Metabolites from marine invertebrates and their symbiotic microorganisms: molecular diversity discovery, mining, and application显示文摘Metabolites from marine organisms have proven to be a rich source for the discovery of multiple potent bioactive moleculeswith diverse structures. In recent years, we initiated a program to investigate the diversity of the secondary metabolites frommarine invertebrates and their symbiotic microorganisms collected from the South China Sea. In this review, representativecases are summarized focusing on molecular diversity, mining, and application of natural products from these marineorganisms. To provide a comprehensive introduction to the field of marine natural products, we highlight typical moleculesincluding their structures, chemical synthesis, bioactivities and mechanisms, structure-activity relationships as well as biogenesis. The mining of marine-derived microorganisms to produce novel secondary metabolites is also discussed through theOSMAC strategy and via partial chemical epigenetic modification. A broad prospectus has revealed a plethora of bioactivenatural products with novel structures from marine organisms, especially from soft corals, gorgonians, sponges, and theirsymbiotic fungi and bacteria. | Lu Liu Yao-Yao Zheng Chang-Lun Shao Chang-Yun Wang | 2019 | Marine Life Science & Technology2019，1，1： | 13 |
| 2 | Vibrioharveyi: a serious pathogen offish and invertebrates in mariculture显示文摘Vibrio harveyi,which belongs to family Vibrionaceae of class G cunmap rote obacte ria,includes the species V.car char iae and V.trachuri as its junior synonyms.The organism is a well-recognized and serious bacterial pathogen of marine fish and invertebrates,including penaeid shrimp,in aquaculture.Diseased fish may exhibit a range of lesions,including eye lesions/blindness,gastro-enteritis,muscle necrosis,skin ulcers,and tail rot disease.In shrimp,V.harveyi is regarded as the etiological agent of luminous vibriosis in which affected animals glow in the dark.There is a second condition of shrimp known as Bolitas negricans where the digestive tract is filled with spheres of sloughed-off tissue.It is recognized that the pathogenicity mechanisms of V.harveyi may be different in fish and penaeid shrimp.In shrimp,the pathogenicity mechanisms involved the endotoxin lipopolysaccharide,and extracellular proteases,and interaction with bacteriophages.In fish,the pathogenicity mechanisms involved extracellular hemolysin(encoded by duplicate hemolysin genes),which was identified as a phospholipase B and could inactivate fish cells by apoptosis,via the caspase activation pathway.V.harveyi may enter the so-called viable but nonculturable(VBNC)state,and resuscitation of the VBNC cells may be an important reason for vibriosis outbreaks in aquaculture.Disease control measures center on dietary supplements(including probiotics),nonspecific immunostimulants,and vaccines and to a lesser extent antibiotics and other antimicrobial compounds. | Xiao-Hua Zhang Xinxin He Brian Austin | 2020 | Marine Life Science & Technology2020，2，3： | 6 |
| 3 | Viable but nonculturable bacteria and their resuscitation:implications for cultivating uncultured marine microorganisms显示文摘Culturing has been the cornerstone of microbiology since Robert Koch first successfully cultured bacteria in the late nineteenth century. However, even today, the majority of microorganisms in the marine environment remain uncultivated. There are various explanations for the inability to culture bacteria in the laboratory, including lack of essential nutrients, osmotic support or incubation conditions, low growth rate, development of micro-colonies, and the presence of senescent or viable but nonculturable (VBNC) cells. In the marine environment, many bacteria have been associated with dormancy, as typified by the VBNC state. VBNC refers to a state where bacteria are metabolically active, but are no longer culturable on routine growth media. It is apparently a unique survival strategy that has been adopted by many microorganisms in response to harsh environmental conditions and the bacterial cells in the VBNC state may regain culturability under favorable conditions. The resuscitation of VBNC cells may well be an important way to cultivate the otherwise uncultured microorganisms in marine environments. Many resuscitation stimuli that promote the restoration of culturability have so far been identified;these include sodium pyruvate, quorum sensing autoinducers, resuscitation-promoting factors Rpfs and YeaZ, and catalase. In this review, we focus on the issues associated with bacterial culturability, the diversity of bacteria entering the VBNC state, mechanisms of induction into the VBNC state, resuscitation factors of VBNC cells and implications of VBNC resuscitation stimuli for cultivating these otherwise uncultured microorganisms. Bringing important microorganisms into culture is still important in the era of high-throughput sequencing as their ecological functions in the marine environment can often only be known through isolation and cultivation. | Xiao-Hua Zhang Waqar Ahmad Xiao-Yu Zhu Jixiang Chen Brian Austin | 2021 | Marine Life Science & Technology2021，3，2： | 6 |
| 4 | Microbial assembly, interaction, functioning, activity and diversification: a review derived from community compositional data显示文摘Microorganisms play crucial roles in maintaining ecosystem stability. The last two decades have witnessed an upsurge instudies on marine microbial community composition using high-throughput sequencing methods. Extensive mining ofthe compositional data has provided exciting new insights into marine microbial ecology from a number of perspectives.Both deterministic and stochastic processes contribute to microbial community assembly but their relative importance instructuring subcommunities, that are categorized by traits such as abundance, functional type and activity, differs. Throughcorrelation-based network analysis, significant progress has been made in unraveling microbial co-occurrence patterns anddynamics in response to environmental changes. Prediction of ecosystem functioning, based on microbial data, is receivingincreasing attention, as closely related microbes often share similar ecological traits and microbial diversity often exhibitssignificant correlations to ecosystem functioning. The ecosystem functioning is likely executed not by the whole community,but rather by an active fraction of a community, which can be inferred from the marker gene transcription level of communitymembers. Furthermore, the huge amount of microbial community data has significantly expanded the tree of lifeand illuminated microbial phylogenetic divergence and evolutionary history. This review summarizes important findingsin microbial assembly, interaction, functioning, activity and diversification, highlighting the interacting roles of differentaspects, derived from community compositional data. | Jiwen Liu Zhe Meng Xiaoyue Liu Xiao-Hua Zhang | 2019 | Marine Life Science & Technology2019，1，1： | 5 |
| 5 | Diversity of culturable heterotrophic bacteria from the Mariana Trench and their ability to degrade macromolecules显示文摘The Mariana Trench is the deepest location on earth and harbors unique microbial communities as evidenced by 16S rRNA gene amplicon and metagenomic sequencing.Obtaining culturable microorganisms from the Mariana Trench will contribute to a further understanding of hadal biogeochemical processes and act as a unique microbial reservoir with potential applications.Here,825 bacterial strains,identified by 16S rRNA gene sequencing,were isolated from 12 water depths(0-10,400 m)of the Mariana Trench with 2216E and R2A media at 4℃ or 28℃ on four cruises during 2015-2017.These bacteria belong to four phyla,nine classes,27 orders,45 families and 108 genera.Alphaproteobacteria,Gammaproteobacteria,Actinobacteria_c,Bacilli and Flavobacteriia were the most abundant classes,accounting for 37.9%,33.0%,11.8%,8.6%and 8.0%of the total bacterial isolates,respectively.2216E and R2A media were found to have a better selectivity to Bacilli and Flavobacteriia,respectively.Fifty strains were potential novel bacterial species with a 16S rRNA gene similarity<98.65%,and a higher percentage of novel strains were obtained from R2A than 2216E medium.Additionally,301(150 species)out of 354 strains(178 species)selected from each depth could degrade at least one of the ten kinds of macromolecules tested.These results indicate that there is a high diversity of culturable bacteria in the Mariana Trench and they can produce a variety of extracellular enzymes.Our study provides a valuable resource of microorganisms for investigating their biogeochemical roles in the Mariana Trench and for industrial applications. | Xiuxiu Zhao Jiwen Liu Shun Zhou Yanfen Zheng Yanhong Wu Kazuhiro Kogure Xiao-Hua Zhang | 2020 | Marine Life Science & Technology2020，2，2： | 5 |
| 6 | The intriguing chemistry and biology of sulfur-containing natural products from marine microorganisms(1987-2020)显示文摘Natural products derived from marine microorganisms have received great attention as a potential resource of new compound entities for drug discovery.The unique marine environment brings us a large group of sulfur-containing natural products with abundant biological functionality including antitumor,antibiotic,anti-inflammatory and antiviral activities.We reviewed all the 484 sulfur-containing natural products(non-sulfated)isolated from marine microorganisms,of which 59.9%are thioethers,29.8%are thiazole/thiazoline-containing compounds and 10.3%are sulfoxides,sulfones,thioesters and many others.A selection of 133 compounds was further discussed on their structure-activity relationships,mechanisms of action,biosynthesis,and druggability.This is the first systematic review on sulfur-containing natural products from marine microorganisms conducted from January 1987,when the first one was reported,to December 2020. | Yang Hai Mei-Yan Wei Chang-Yun Wang Yu-Cheng Gu Chang-Lun Shao | 2021 | Marine Life Science & Technology2021，3，4： | 5 |
| 7 | Receptor,signal transduction and evolution of sweet,umami and bitter taste显示文摘Like olfaction,the sense of taste allows the detection and discrimination of chemicals in the environment.However,while olfaction is specialized in the detection of volatile chemicals,taste is restricted to the detection of contact-chemicals.Two families of mammalian taste receptors,T1R and T2R,involved in recognition of sweet,umami(the taste of monosodium glutamate)and bitter stimuli have been identified and characterized.Although much progress has been made in studies on the basic mechanisms of taste recognition and signal transduction in mammals,we are still far from a full understanding of different taste qualities.This review presents a current perspective on sweet,bitter and umami taste receptors and their signal transduction mechanism.We also discuss the evolution of taste and taste-related molecules. | Zhongmei Ren Zhenhui Liu | 2020 | Marine Life Science & Technology2020，2，1： | 4 |
| 8 | Our recent progress in epigenetic research using the model ciliate, Tetrahymena thermophila显示文摘Epigenetic research focuses on heritable changes beyond the DNA sequence, which has led to a revolution in biologicalstudies and benefits in many other fields. The well-known model ciliate, Tetrahymena thermophila offers a unique system forepigenetic studies due to its nuclear dimorphism and special mode of sexual reproduction (conjugation), as well as abundantgenomic resources and genetic tools. In this paper, we summarize recent progress made by our research team and collaboratorsin understanding epigenetic mechanisms using Tetrahymena. This includes: (1) providing the first genome-wide basepair-resolution map of DNA N6-methyladenine (6mA) and revealed it as an integral part of the chromatin landscape;(2)dissecting the relative contribution of cis・ and trans- elements to nucleosome distribution by exploring the unique nucleardimorphism of Tetrahymena, (3) demonstrating the epigenetic controls of RNAi-dependent Polycomb repression pathwayson transposable elements, and (4) identifying a new histone monomethyltransferase, TXR1 (Tetrahymena Trithorax 1), thatfacilitates replication elongation through 让s substrate histone H3 lysine 27 monomethylation (H3K27mel). | Ting Cheng Yuanyuan Wang Jie Huang Xiao Chen Xiaolu Zhao Shan Gao Weibo Song | 2019 | Marine Life Science & Technology2019，1，1： | 4 |
| 9 | From ecophysiology to cultivation methodology:filling the knowledge gap between uncultured and cultured microbes显示文摘Earth is dominated by a myriad of microbial communities,but the majority fails to grow under in situ laboratory conditions.The basic cause of unculturability is that bacteria dominantly occur as biofilms in natural environments.Earlier improvements in the culture techniques are mostly done by optimizing media components.However,with technological advancement particularly in the field of genome sequencing and cell imagining techniques,new tools have become available to understand the ecophysiology of microbial communities.Hence,it becomes easier to mimic environmental conditions in the culture plate.Other methods include co-culturing,emendation of growth factors,and cultivation after physical cell sorting.Most recently,techniques have been proposed for bacterial cultivation by employing genomic data to understand either microbial interactions(network-directed targeted bacterial isolation)or ecosystem engineering(reverse genomics).Hopefully,these techniques may be applied to almost all environmental samples,and help fill the gaps between the cultured and uncultured microbial communities. | Nimaichand Salam Wen-Dong Xian Mipeshwaree Devi Asem Min Xiao Wen-Jun Li | 2021 | Marine Life Science & Technology2021，3，2： | 4 |
| 10 | Environmental perspectives of microplastic pollution in the aquatic environment:a review显示文摘Microplastics are a highly concerning pollutant that have gained attention from the scientific community and other regulatory authorities due to their potential risks to organisms and ecosystems.Microplastics are widespread in both terrestrial and aquatic ecosystems and can be found even in Antarctica and deep-sea sediments.The ability to survive for long periods in the environment and their aptitude of inter-and intra-environmental translocation can prompt poor environmental outcomes.The adsorption of heavy metals and other toxic persistent organic pollutants is a further cause for concern.Furthermore,microplastics enable the development of a distinct microbial niche within an ecosystem,which could potentially impair ecosystem function by promoting the growth of selective microbial communities.The acquisition of metal-resistant,antibiotic-resistant genes,and the enrichment of antibiotic-resistant bacteria on microplastic surfaces have recently been reported.Moreover,some studies have also reported the colonizahon of pathogenic bacterial strains such as Vibrio spp.on microplastic surfaces.This review aims to address the sources of microplastic pollution in the freshwater and marine environments and to discuss their potential functions in the environment. | Manzoor Ahmad Jia-Ling Li Pan-Deng Wang Wael NHozzein Wen-Jun Li | 2020 | Marine Life Science & Technology2020，2，4： | 4 |
| 11 | Co-culture:stimulate the metabolic potential and explore the molecular diversity of natural products from microorganisms显示文摘Microbial secondary metabolites have long been considered as potential sources of lead compounds for medicinal use due to their rich chemical diversity and extensive biological activities.However,many biosynthetic gene clusters remain silent under traditional laboratory culture conditions,resulting in repeated isolation of a large number of known compounds.The co-culture strategy simulates the complex ecological environment of microbial life by using an ecology-driven method to activate silent gene clusters of microorganisms and tap their metabolic potential to obtain novel bioactive secondary metabolites.In this review,representative studies from 2017 to 2020 on the discovery of novel bioactive natural products from co-cultured microorganisms are summarized.A series of natural products with diverse and novel structures have been discovered successfully by co-culture strategies,including fungus-fungus,fungus-bacterium,and bacterium-bacterium co-culture approaches.These novel compounds exhibited various bioactivities including extensive antimicrobial activities and potential cytotoxic activities,especially when it came to disparate marine-derived species and cross-species of marine strains and terrestrial strains.It could be concluded that co-culture can be an effective strategy to tap the metabolic potential of microorganisms,particularly for marine-derived species,thus providing diverse molecules for the discovery of lead compounds and drug candidates. | Xiao-Yue Peng Jin-Tao Wu Chang-Lun Shao Zhi-Yong Li Min Chen Chang-Yun Wan | 2021 | Marine Life Science & Technology2021，3，3： | 4 |
| 12 | Visual detection of tropomyosin,a major shrimp allergenic protein using gold nanoparticles(AuNPs)-assisted colorimetric aptasensor显示文摘A gold nanoparticle-based label-free colorimetric assay was developed to detect the shrimp allergenic protein tropomyosin(TM),an important biomarker responsible for severe clinical reactivity to shellfish.In a gold nanoparticles(AuNPs)-tropomyosin-binding aptamer(TMBA)complex,the aptamer adsorbs onto the surface of AuNPs and dissociates in the presence of TM.In addition,AuNPs tend to aggregate in the presence of ionic salt,revealing a color change(i.e.,wine-red to purple/blue)with a shift in the maximum absorption peak from 520 nm.In the presence of specific binding TM,the aptamer folds into a tertiary structure where it more efficiently stabilizes AuNPs toward the salt-induced aggregation with a hypsochromic shift in the absorption spectra compared to the stabilized AuNPs by aptamer alone.Based on the aggregation and sensitive spectral transformation principle,the AuNPs-based colorimetric aptasensor was successfully applied to detect TM with a range of 10-200 nmol/L and a low detection limit of 40 nmol/L in water samples.The reliability,selectivity,and sensitivity of the aptasensor was then tested with food samples spiked with TM.The observed detection limit was as low as 70 nmol/L in shrimp,90 nmol/L in tofu,and 80 nmol/L in eggs,respectively.We anticipate the proposed AuNPs-based colorimetric aptasensor assay possesses a high potential for the easy and efficient visual colorimetric detection of TM. | Tushar Ramesh Pavase Hong Lin Maqsood Ahmed Soomro Hongwei Zheng Xiaxia Li Kexin Wang Zhenxing Li | 2021 | Marine Life Science & Technology2021，3，3： | 3 |
| 13 | Structure modification,antialgal,antiplasmodial,and toxic evaluations of a series of new marine-derived 14-membered resorcylic acid lactone derivatives显示文摘Marine natural products play critical roles in the chemical defense of many marine organisms and are essential,reputable sources of successful drug leads.Sixty-seven 14-membered resorcylic acid lactone derivatives 3–27 and 30–71 of the natural product zeaenol(1)isolated from the marine-derived fungus Cochliobolus lunatus were semisynthesized by chlorination,acylation,esterification,and acetalization in one to three steps.The structures of these new derivatives were established by HRESIMS and NMR techniques.All the compounds(1–71)were evaluated for their antialgal and antiplasmodial activities.Among them,14 compounds displayed antifouling activities against adhesion of the fouling diatoms.In particular,9 and 34 exhibited strong and selective inhibitory effects against the diatoms Navicula laevissima and Navicula exigua(EC50=6.67 and 8.55μmol/L),respectively,which were similar in efficacy to those of the positive control SeaNine 211(EC50=2.90 and 9.74μmol/L).More importantly,38,39,and 69–71 showed potent antiplasmodial activities against Plasmodium falciparum with IC50 values ranging from 3.54 to 9.72μmol/L.Very interestingly,the five antiplasmodial derivatives displayed non-toxicity in the cytotoxicity assays and the zebrafish embryos model,thus,representing potential promising antiplasmodial drug agents.The preliminary structure–activity relationships indicated that biphenyl substituent at C-2,acetonide at positions C-5′and C-6′,and tri-or tetra-substituted of acyl groups increased the antiplasmodial activity.Therefore,combining evaluation of chemical ecology with pharmacological models will be implemented as a systematic strategy,not only for environmentally friendly antifoulants but also for structurally novel drugs. | Wei-Feng Xu Na-Na Wu Yan-Wei Wu Yue-Xuan Qi Mei-Yan Wei Laura M.Pineda Michelle G.Ng Carmenza Spadafora Ji-Yong Zheng Ling Lu Chang-Yun Wang Yu-Cheng Gu Chang-Lun Shao | 2022 | Marine Life Science & Technology2022，4，1： | 3 |
| 14 | Effective Antarctic krill oil extraction using switchable hydrophilicity solvents显示文摘Antarctic krill has been widely studied because of its abundant biomass,rich nutritional value,and great production potential.Notably,krill oil(KO)is rich in phospholipids(PLs),polyunsaturated fatty acids(PUFAs),and astaxanthin.A method based on a green switchable hydrophilicity solvent N,7V-dimethyIcyclohexylamine(DMCHA),which can reversibly change from oil soluble to water soluble in the presence of CO2 was used to extract KO from frozen Antarctic krill as it consumes less energy than traditional methods.We showed that DMCHA destroyed the surface structure of Antarctic krill and accelerated the dissolution of KO.In addition,this method enabled the PL extraction to reach up to 80.2%of total PLs,among which PC accounted for the highest proportion,up to 90.91%in PL.In fact,the astaxanthin extraction reached up to 81.44%of total astaxanthin while the fatty acid(FA)extraction up to 84.35%.The KO extracted through DMCHA was rich in PUFA,up to 47.74%,and the content of EPA+DHA reached 42.16%of total FA content.Furthermore,the amount of residual solvent in the lipid phase was just 0.23%of the DMCHA used for the extraction and the recovery rate of solvent was up to 93.2%.Our results demonstrated the high efficiency of oil extraction and the environmental friendliness of this method. | Weiwei Sun Wencan Hua Bowen Shi Changhu Xue Xiaoming Jiang | 2020 | Marine Life Science & Technology2020，2，1： | 3 |
| 15 | Strategies for culturing active/dormant marine microbes显示文摘Microorganisms are ubiquitous in the ocean environment and they play key roles in marine ecosystem function and service.However,many of their functions and phenotypes remain unknown because indigenous marine bacteria are mostly difficult to culture.Although many novel techniques have brought previously uncultured microbes into laboratory culture,there are still many most-wanted or key players that need to be cultured from marine environments.This review discusses possible reasons for‘unculturable microbes’and categorizes uncultured bacteria into three groups:dominant active bacteria,rare active bacteria,and dormant bacteria.This review also summarizes advances in cultivation techniques for culturing each group of unculturable bacteria.Simulating the natural environment is an effective strategy for isolating dominant active bacteria,whereas culturomics and enrichment culture methods are proposed for isolating rare active bacteria.For dormant bacteria,resuscitation culture is an appropriate strategy.Furthermore,the review provides a list of the most-wanted bacteria and proposes potential strategies for culturing these bacteria in marine environments.The review provides new insight into the development of strategies for the cultivation of specific groups of uncultured bacteria and therefore paves the way for the detection of novel microbes and their functions in marine ecosystems. | Da-Shuai Mu Yang Ouyang Guan-Jun Chen Zong-Jun Du | 2021 | Marine Life Science & Technology2021，3，2： | 3 |
| 16 | The role of bacterial signaling networks in antibiotics response and resistance regulation显示文摘Excessive use of antibiotics poses a threat to public health and the environment.In ecosystems,such as the marine environment,antibiotic contamination has led to an increase in bacterial resistance.Therefore,the study of bacterial response to antibiotics and the regulation of resistance formation have become an important research field.Traditionally,the processes related to antibiotic responses and resistance regulation have mainly included the activation of efflux pumps,mutation of antibiotic targets,production of biofilms,and production of inactivated or passivation enzymes.In recent years,studies have shown that bacterial signaling networks can affect antibiotic responses and resistance regulation.Signaling systems mostly alter resistance by regulating biofilms,efflux pumps,and mobile genetic elements.Here we provide an overview of how bacterial intraspecific and interspecific signaling networks affect the response to environmental antibiotics.In doing so,this review provides theoretical support for inhibiting bacterial antibiotic resistance and alleviating health and ecological problems caused by antibiotic contamination. | Yuying Li Tao Feng Yan Wang | 2022 | Marine Life Science & Technology2022，4，2： | 3 |
| 17 | Report of epibenthic macrofauna found from Haima cold seeps and adjacent deep-sea habitats,South China Sea显示文摘This work reports on a preliminary taxonomic study of epibenthic macroinvertebrates collected or observed by underwater video at the Haima cold seeps and in adjacent deep-sea habitats,including a mud volcano feld and Ganquan Plateau,during an expedition in the South China Sea by the Chinese-manned submersible Shenhai Yongshi in May 2018.A total of 41 species belonging to 6 phyla were identifed,among which 34 species were collected from the Haima cold seeps.Mollusks and crustaceans that are specialized in reducing habitats were predominant in biotopes of the Haima cold seeps,whereas sponges and cold-water corals and their commensals were prominent in communities of the mud volcano feld and the slopes of Ganquan Plateau.The distribution and faunal composition of each taxonomic group are discussed. | Dong Dong Xinzheng Li Mei Yang Lin Gong Yang Li Jixing Sui Zhibin Gan Qi Kou Ning Xiao Junlong Zhang | 2021 | Marine Life Science & Technology2021，3，1： | 3 |
| 18 | The parasitic dinoflagellate Hematodinium infects marine crustaceans显示文摘Hematodinium is a type of parasitic dinoflagellate that infects marine crustaceans globally.The parasite lives mainly in the hemolymph or hemocoels of affected hosts,and results in mortalities due to malfunction or loss of functions of major organs.In recent years,the parasite had developed into an emerging epidemic pathogen not only affecting wild populations of economically valuable marine crustaceans in western countries but also the sustainable yield of aquaculture of major crabs in China.The epidemics of the parasitic diseases expanded recently in the coastal waters of China,and caused frequent outbreaks in aquaculture of major crab species,especially Portunus trituberculatus and Scylla paramamosain.In addition,the pathogen infected two species of co-cultured shrimps and multiple cohabitating wild crabs,implying it is a significant threat to the sustainable culture of commercially valuable marine crustaceans.In particular,the polyculture system that is widely used along the coast of China may facilitate the spread and transmission of the pathogen.Thus,to provide a better understanding of the biological and ecological characteristics of the parasitic dinoflagellate and highlight important directions for future research,we have reviewed the current knowledge on the taxonomy,life cycle,pathogenesis,transmission and epidemiology of Hematodinium spp.Moreover,ecological countermeasures have been proposed for the prevention and control of the emerging infectious disease. | Caiwen Li Meng Li Qian Huang | 2021 | Marine Life Science & Technology2021，3，3： | 3 |
| 19 | Mapping the potential for offshore aquaculture of salmonids in the Yellow Sea显示文摘Mariculture has been one of the fastest-growing global food production sectors over the past three decades.With the congestion of space and deterioration of the environment in coastal regions,offshore aquaculture has gained increasing attention.Atlantic salmon(Salmo salar)and rainbow trout(Oncorhynchus mykiss)are two important aquaculture species and contribute to 6.1%of world aquaculture production of finfish.In the present study,we established species distribution models(SDMs)to identify the potential areas for offshore aquaculture of these two cold-water fish species considering the mesoscale spatio-temporal thermal heterogeneity of the Yellow Sea.The values of the area under the curve(AUC)and the true skill statistic(TSS)showed good model performance.The suitability index(SI),which was used in this study to quantitatively assess potential offshore aquaculture sites,was highly dynamic at the surface water layer.However,high SI values occurred throughout the year at deeper water layers.The potential aquaculture areas for S.salar and O.mykiss in the Yellow Sea were estimated as 52,270±3275(95%confidence interval,CI)and 146,831±15,023 km^(2),respectively.Our results highlighted the use of SDMs in identifying potential aquaculture areas based on environmental variables.Considering the thermal heterogeneity of the environment,this study suggested that offshore aquaculture for Atlantic salmon and rainbow trout was feasible in the Yellow Sea by adopting new technologies(e.g.,sinking cages into deep water)to avoid damage from high temperatures in summer. | Shuang‑En Yu Shuang‑Lin Dong Zhi‑Xin Zhang Yu‑Yang Zhang Gianluca Sarà Jie Wang Yun‑Wei Dong | 2022 | Marine Life Science & Technology2022，4，3： | 2 |
| 20 | Fine‑mapping and association analysis of candidate genes for papilla number in sea cucumber,Apostichopus japonicus显示文摘The papilla number is one of the most economically important traits of sea cucumber in the China marketing trade.However,the genetic basis for papilla number diversity in holothurians is still scarce.In the present study,we conducted genomewide association studies(GWAS)for the trait papilla number of sea cucumbers utilizing a set of 400,186 high-quality SNPs derived from 200 sea cucumbers.Two significant trait-associated SNPs that passed Bonferroni correction(P<1.25E−7)were located in the intergenic region near PATS1 and the genic region of EIF4G,which were reported to play a pivotal role in cell growth and proliferation.The fine-mapping regions around the top two lead SNPs provided precise causative loci/genes related to papilla formation and cellular activity,including PPP2R3C,GBP1,and BCAS3.Potential SNPs with P<1E−4 were acquired for the following GO and KEGG enrichment analysis.Moreover,the two lead SNPs were verified in another population of sea cucumber,and the expressive detection of three potential candidate genes PATS1,PPP2R3C,and EIF4G that near or cover the two lead SNPs was conducted in papilla tissue of TG(Top papilla number group)and BG(Bottom papilla number group)by qRT-PCR.We found the significantly higher expression profile of PATS1(3.34-fold),PPP2R3C(4.90-fold),and EIF4G(4.23-fold)in TG,implying their potential function in papilla polymorphism.The present results provide valuable information to decipher the phenotype differences of the papilla trait and will provide a scientific basis for selective breeding in sea cucumbers. | Xinghai Zhu Ping Ni Marc Sturrock Yangfan Wang Jun Ding Yaqing Chang Jingjie Hu Zhenmin Bao | 2022 | Marine Life Science & Technology2022，4，3： | 2 |
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